RESUMO
Background: obesity may establish a crucial barrier for effective fertility treatment in polycystic ovary syndrome [PCOS] females
Objective: to compare results of intra-cytoplasmic sperm injection [ICSI] in females with and without polycystic ovarian syndrome and further appraise the effect of obesity in PCOS females
Materials and Methods: a cross-sectional study from June 2015 to July 2016 included non-PCOS and PCOS [recognized by Rotterdam criteria] females who underwent ICSI. The PCOS were further stratified into non-obese and Obese according to the South Asian criteria for body mass index. Results were categorized on the basis of beta-human chorionic gonadotropin [beta-hCG] and transvaginal scan into non-pregnant [beta-hCG <25 mIU/ml], preclinical abortion [beta-hCG >25 mIU/ml with no fetal cardiac activity] and clinical pregnancy [beta-hCG >25 mIU/ml with fetal cardiac activity on transvaginal scan]. In addition, reproductive outcomes; implantation rate, clinical pregnancy rate and miscarriage rate among obese and non-obese PCOS and non-PCOS patients were compared
Results: our results revealed 38.5% clinical pregnancy rate in non-PCOs females, 23.8% in non-obese PCOS females whereas 26.4% in obese PCOS. Preclinical abortions were found to be highest [31.5%] in non-obese PCOS females and were the lowest [26.2%] in non-PCOS females. In non-PCOS group and non-obese PCOS females 35.4% and 44.6%, respectively, failed to become pregnant
Conclusion: the success after ICSI in terms of number of clinical pregnancies was more in non-PCOS patients as compared to PCOS. Increase in body mass index reflected a negative impact on the reproductive outcome in PCOS patients