RESUMO
A series of 5-[3'-oxo-6'-[substituted aryl]-2',3',4',5'-tetrahydropyridazin-2'-yl methyl]-2-substituted 1,3,4-oxadiazole has been synthesized. Appropriate aromatic hydrocarbon reacts with succinic anhydride in presence of AlCl[3] to yield beta-Aroyl propionic acid [1a]. The corresponding acid is cyclised with hydrazine hydrate to give 6-[substituted aryl]-2,3,4,5-tetrahydro3-pyridazinone [1b]. This intermediate after reaction with ethyl bromo acetate, hydrazinolysed into 3-oxo-6-[substituted aryl]-2,3,4,5-tetrahydropyridazinyl acetohydrazide [1c]. The resulting product was converted into 5-[3'oxo-6'-[substituted aryl]-2',3',4',5'-tetrahydropyridazin-2'-yl methyl]-2-substituted 1,3,4-oxadiazole [Scheme-I]. All the final compounds have been structurally elucidates on the basis of IR, [1]H-NMR, mass spectral data and elemental analysis and screened for antitubercular activity