RESUMO
The biochemical and histological changes induced by palm kernel oil and the protective effect of Crataegus Oxyacantha [a fruit-bearing shrub] is evaluated. Its therapeutic benefit has been recorded for treatment of cardiovascular disease [angina-hypertensionarrhythmias and congestive heart failure], in addition to its potential use as anti-ischemic and lipid lowering agent. Male albino rats were treated with oral dosage of 10ml/kg b.w. /day palm kernel oil for a total experimental duration of one month. Biochemical studies of total cholesterol, LDL -cholesterol and triglycerides perceived high values in their serum concentrations along with abnormal proteins profile. Induced histopathological lesions in the cardiovascular system were represented by disruption in intimal layer of both arteries and viens, subendothelial deposition of fats, foam cells and formation of fibrotic areas. The tunica media however showed mild fibrosis with chronic inflammatory cells. Simultaneously cardiac muscles were infiltrated with various sizes of fat droplets, loss of muscle striation and occupied by lymphocytes, macrophage and plasma cells On the other hand Crataegus oxyacantha at a dosage of 0.5ml /kg.b.w. /day were orally given to Palm Kernel Oil group. A similar dosage were given as crataegus treated group only for a duration of one month. Crataegus oxyacantha potentiated a counteractive effect on palm kernel oil treated group, presented in restitution of biochemical alteration and amended cardiovascular changes. These findings were attributed to the significant inhibitory effect of Crataegus remedy adjoining deleterious effects of palm kernel oil