RESUMO
One hundred sixty adult albino rats were deployed into 8 equal groups, each of 20 rats. The first group [I] received tenoxicam daily orally for 14 days at a dose of 20 mg/kg bw. The second group [II] received tenoxicam together with misoprostol in a dose of 16 mg/kg bw daily orally. The third group [I: T1] received tenoxicam as in group I together with omeprazole in a dose of 20 mg/kg bw daily orally for the same period. The fourth group [IV] received tenoxicam together with misoprostol and omeprazole at the previously mentioned doses and duration. There were four control groups, one negative control group and three positive control groups, received gum acacia in distilled water, misoprostol and omeprazole groups in doses equivalent to those given to the test groups. At the end of the study, the rats were sacrificed 24 hours after drug administration. Liver and kidney functions were investigated. Serum pancreatic amylase, blood platelets and hemoglobin were also determined. Histopathological examination of liver, kidney, stomach, duodenum and pancreas were done