[ case report of rare colorectal adenocarcinoma with skin metastasis presentation]

Skin metastasis from abdominal cancers occurs as infiltration or paraneoplastic syndromes. Liver and lung are the most common locations of distant metastases of colorectal cancer [CRC], but CRC skin metastases are very rare. We describe a 55-year old patient with wide spread cutaneous metastasis from a previously treated known case of adenocarcinoma of the colon. Interestingly, liver and lung, as the most common site of metastasis of CRC, had not been involved. Although, skin metastasis is a worse prognostic factor, its occurrence in CRC patient doesn't necessarily present end stage disease. So, it could be treated by early diagnosis of susceptible cutaneous lesions

[ case report of junctional epidermolysis bullosa with gastrointestinal symptoms]

Epidermolysis bullosa is an uncommon disease with a wide spectrum of severity. Here we report a patient presenting with unusual symptoms. The patient is a 22 years old female with progressive dysphasia and odynophagia to solids and liquids and a history of spontaneously remitting blisters caused after mild trauma from her childhood till she was 13 years old. Subepidermal blisters were diagnosed as junctional type of epidermolysis bullosa by histopathology. Physicians should have a high index of suspicion regarding epidermolysis bullosa in patients presenting with dysphagia and cutaneous blisters