Antinociceptive effects of hydroalcoholic extract of thymus vulgaris

Previous investigation has shown that Thymus Vulgaris [TV] modulates pain. The aim of this work was to examine the role of TV on acute and chronic pain and compares its effect with dexamethasone [DEX] and stress [ST] by using Hot plate, Tail flick and Formalin tests in mice. In this study male albino mice [25-30 g.] in 21 groups [n = 147] were used. TV [100, 500 and 1000mg/kg], DEX [0.5, 1 and 2 mg/kg] and vehicle [VEH] were injected 30 minutes before pain assessment tests. Stress was applied by 1 min swimming in cold water [18 - 22°]. Acute and chronic pain was assessed by Hot plate, Tail flick and Formalin tests. For assessment of the role of opioid receptors in antinoceception of TV extract, Naloxon [NAL, 2mg/kg, ip] as opioid receptor antagonist was injected before the injection of the more effective dose [500mg/kg] of TV extract. Results indicated that TV, DEX and ST have analgesic effects in all tests [P < 0.01 in comparison with control group]. Above findings showed that TV extract, DEX and ST have modulatory effects on acute and chronic pain. Further research is required to determine the mechanisms by which TV extract has an inhibitory effect on pain sensation

effect of hydroalcoholic matricaria chamomilla extract on cutaneous burn wound healing in albino rats

On the bases of the antiinflammatory, antimicrobial and antioxidant effects of matricaria chamomilla [chamomile] extract. This study was design to determine the effect of topical hydroalcoholic chamomile extract on burn wound healing in albino Rats. In this experimental study 30 male albino Rats were randomly divided into 3 equal groups, as sham, control [olive oil] and treatment. Second degree burning was induced in 20% of whole surface area of animal body by diving the back of animal into boiling water for 8 seconds. Animals of control group received no treatment. Animals of olive oil and treatment groups were treated topically by olive oil and hydroalcoholic extract dissolved in olive oil twice a day respectively from the first day of burn induction to complete wound healing. The results showed that there was not significant difference between olive oil and sham groups in all days of experiments. Also there was significant difference in wound healing [p < 0.05] between olive oil and treatment groups [62.96 +/- 2.70 versus 74.77 +/- 2.50] from the day of 20 to the end of experiments. This study showed that the hydroalcoholic chamomile extract has a treatment effect on burn wound healing in animal model