Haemostatic activation in acute coronary syndrome patients in relation to physical exercise

Thrombosis is regarded to be a key factor in the development of acute coronary syndromes in patients with coronary artery disease [CAD], Platelets are known to play a fundamental role in acute coronary syndromes [ACS]. After atherosclerotic plaque rupture, platelets can form pathogenic, occlusive thrombi leading to acute ischemic events. The precise mechanisms of platelet activation in acute coronary syndromes are still under investigation. Physical activity could regulate the development of ACS via effects on platelet function. Several studies have shown that acute physical exercise increases platelet reactivity, typically assessed by aggregation assays, in both healthy individuals and in patients with cardiovascular disease. The aim of this study was to investigated the effect of moderate and strenuous exercise on arterial thrombus formation. Assay of some hemostatic marker as Platelet activation, thrombin generation [TF[pg/ml],TAT_ micro g/l and dimerand tPA concentration] von Willebrand factor, platelet aggregation tests, Coronary Angiography. haemostatic parameters in patients with ACS correlated with other clinical parameters under physical exercise Patients with ACS showed higher values for fibrinogen, tPA, TAT_, as indicators for a thrombin synthesis, and a marker for prothrombotic conditions, was elevated in patients with ACS,. Von Willebrand factor and D-dimer showed no statistical significant differences during rest., Exercise increased hemostatic parameters in an strenuous physical exercise in ACS Patients[< 0.05]. Exercise also increased plasma levels of fibrinogen and von Willebrand factor ,but there was an increase in the generation of T-AT complexes,. [P < 0.05]. Exercise did not affect platelet aggregation regardless of its intensity when triggered by the agonists ADP or collagen. Strenuous but not moderate exercise increases the thrombotic tendency in healthy sedentary male volunteers

Serum 25 hydroxy vitamin D levels in adult asthmatic patients

Patients with chronic lung disease as asthma appear to be at increased risk for vitamin D deficiency for reasons that are not clear. A cross sectional study including 75 asthmatic adults aged older than 18 years and 75 adults healthy control aged older than 18 years [35 males and 40 females for both groups] assessing the relationship between serum 25 hydroxy vitamin D levels and lung function. In our study only [12.31%] of our asthmatic adults had sufficient vitamin D levels [>/=30 ng/ml], wherase [85%] of healthy control subjects expressed sufficient levels. Vitamin D deficiency [<20 ng/ml] was observed in 59 [78.66%] asthmatic patients [17.28 +/- 2.4 ng/ml]. Deficiency was not observed in controls [33.67 +/- 6.3]. In asthmatic patients Serum 25 [OH] vitamin D was positively correlated with forced expiratory volume in 1 second% [FEV1%] predicted andforced expiratory/forced vital capacity ratio [FEV1/FVC][P=<0.05 for all]. There was no significant association between serum vitamin D level and eosinophil count. Reduced vitamin D levels are highly prevalent in adult asthmatic patients and are associated with impaired pulmonary functions