RESUMO
Determinar la incidencia de duplicaciones del Tubo Digestivo en niños, en un período de 10 años. Estudio descriptivo, transversal, retrospectivo. Revisión de historias clínicas y biopsias en el Hospital de Niños JM de Los Ríos, desde 1998 a 2008. Variables: edad, sexo, presentación clínica, órgano duplicado, estudio diagnóstico y tratamiento. Se reportarón 11 pacientes con quistes de duplicación, 28% eran recién nacidos, 73% del sexo femenino. Predominó el dolor abdominal como síntoma de presentación en 28%. Se realizó diagnóstico prenatal en 18%. El órgano duplicado predominante fue intestino delgado 55%. Se realizó ecografía abdominal a 7 pacientes y de éstos en un 71% se diagnosticó duplicación intestinal antes de la cirugía. Se realizó exploración a cielo abierto en todos los casos y en 82% se realizó resección total del quiste. Las duplicaciones del tubo digestivo son poco frecuentes. El diagnóstico prenatal permite corregir el defecto en edades tempranas y disminuir su morbilidad. La ecografía es un método útil para el diagnóstico. La resección total de la duplicación es el tratamiento ideal...
Determining the incidence of duplications of digestive tube in children, during a 10-year term. Retrospective cross-sectioned descriptive study. Review of clinical records and biopsies in Hospital de Niños JM de Los Ríos, between 1998 and 2008. Variables: age, sex, clinical presentation, duplicated organ, study, diagnosis, and treatment. 11 patients were reported with duplication cysts: 28% was just-born, 73% was female. Abdominal pain prevailed as the presentation symptom in 28% of cases. Prenatal diagnosis was performed in 18% of cases. Small intestine was the prevailing duplicated organ: 55% of cases. Abdominal echography was performed in 7 patients, and out of which 71% was diagnosed with intestine duplication before surgery. Open sky exploration was carried out in all cases and total resection of cyst was performed in 82% of all cases. Duplications of the digestive tube uncommon. Prenatal diagnosis allows for correcting such defect in early age, thus reducing morbidity. Echography is a diagnosis helpful method. The ideal treatment for duplication is total resection...
Assuntos
Humanos , Masculino , Feminino , Anormalidades do Sistema Digestório/diagnóstico , Anormalidades do Sistema Digestório/prevenção & controle , Dor Abdominal/patologia , Duplicação Gênica , Cistos/patologia , Sistema Nervoso Entérico/embriologia , Sistema Nervoso Entérico/lesões , Trato Gastrointestinal/lesões , Gastroenterologia , Neonatologia , PediatriaRESUMO
Cadherins are cell-to-cell adhesion molecules that play an important role in the establishment of adherent-type junctions by mediating calcium-dependent cellular interactions. The CDH1 gene encodes the transmembrane glycoprotein E-cadherin which is important in maintaining homophilic cell-cell adhesion in epithelial tissues. E-cadherin interacts with catenin proteins to maintain tissue architecture. Structural defects or loss of expression of E-cadherin have been reported as a common feature in several human cancer types. This study aimed to evaluate the expression of E-cadherin and their correlation with clinical features in microdissected brain tumor samples from 81 patients, divided into 62 astrocytic tumors grades I to IV and 19 medulloblastomas, and from 5 white matter non-neoplasic brain tissue samples. E-cadherin (CDH1) gene expression was analyzed by quantitative real-time polymerase chain reaction. Mann-Whitney, Kruskal-Wallis, Kaplan-Meir, and log-rank tests were performed for statistical analyses. We observed a decrease in expression among pathological grades of neuroepithelial tumors. Non-neoplasic brain tissue showed a higher expression level of CDH1 gene than did neuroepithelial tumors. Expression of E-cadherin gene was higher in astrocytic than embryonal tumors (P = 0.0168). Low-grade malignancy astrocytomas (grades I-II) showed higher CDH1 expression than did high-grade malignancy astrocytomas (grades III-IV) and medulloblastomas (P < 0.0001). Non-neoplasic brain tissue showed a higher expression level of CDH1 gene than grade I malignancy astrocytomas, considered as benign tumors (P = 0.0473). These results suggest that a decrease in E-cadherin gene expression level in high-grade neuroepithelial tumors may be a hallmark of malignancy in dedifferentiated tumors and that it may be possibly correlated with their progression and dissemination.
Assuntos
Humanos , Adolescente , Adulto , Pessoa de Meia-Idade , Caderinas/genética , Perfilação da Expressão Gênica , Neoplasias Neuroepiteliomatosas/genética , Cérebro/metabolismo , Regulação Neoplásica da Expressão Gênica , Neoplasias Neuroepiteliomatosas/patologia , Reação em Cadeia da Polimerase Via Transcriptase Reversa , RNA Mensageiro/genética , RNA Mensageiro/metabolismoRESUMO
En ocasión del Seminario Taller "Intercambio de Experiencias en la Enseñanza de la Salud Pública y Atención Primaria de Salud en las Facultades de Medicina Humana en el Perú", organizado en Cusco por la Facultad de Medicina Humana de UNSAAC, el Programa de Salud Comunitaria en el Trapecio Andino presentó la experiencia de tres años de trabajo con los profesionales que cumplen con el Servicio Rural y Urbano-Marginal de Salud. Con la finalidad de intercambiar puntos de vista con las entidades formadoras, se analiza la relación entre la formación universitaria y la realidad del trabajo rural y en Salud Pública, se describe la propuesta del PSCTA hacia los profesionales SERUMS, formulada como Proyecto SERUMS y Plan de Capacitación, y se ofrecen los principales resultados de la evaluación de experiencias.