RESUMO
Objective To investigate the associations between polymorphisms of organic cation transporter OCTN1/2 (organic cation transporter 1/2) and the susceptibility of Crohn' s disease (CD) through a meta-analysis.Methods Databases of PubMed,EMBASE,MedLine,and CNKI (Chinese),Wanfang (Chinese) were searched for published case control studies on the association between polymorphisms of OCTN1/2 gene and the susceptibility of CD which were published before September 2012.The meta-analysis was applied with Review Manager 4.2 software and Stata 10.0 software.Results Nineteen eligible studies,including 14 from Europeans,3 from Asians,1 from Oceania,and 1 from the US were included in the meta-analysis.In total,significant associations were found between OCTN1/2 polymorphisms and the susceptibility of CD for all genetic models.In subgroup analyses,significant associations were found in the European population for OCTN1/2.Associations were not significant in the non-European population for OCTN1 (TT vs.CT:OR=1.25,95％CI:0.75-1.98,P=0.34; TT vs.CC+CT:OR=l.48,95％CI:0.95-2.29,P=0.08) and for OCTN2 (CC vs.GC:OR=1.03,95％CI:0.68-1.56,P=0.89; CC vs.GG + GC:OR=1.23,95％CI:0.83-1.82,P=0.31).However,there were significant associations found between OCTN1/2(TT vs.CC,TT+CT vs.CC,CC vs.GG,CC + GC vs.GG) polymorphisms and the susceptibility of CD found in the nonEuropean population.Conclusion Results from this meta-analysis suggested that OCTN1/2 polymorphisms were associated with the susceptibility of CD in the European population.Associations between OCTN1/2 polymorphisms and the susceptibility of CD in the non-European population required searching for large samples to confirm the findings.
RESUMO
Objective To study the influence of central obesity on clustering of other metabolic syndrome (MS) risk variables among adults with normal body mass index.Methods Through cluster multistage and random sampling methods,local people aged ＞35 years old with normal body mass index (BMI=18.5-24.9 kg/m2) in Lanxi country were selected.Overnight fasting blood specimens of these people were collected.Chi-square test,analysis of covariance,and logistic regression analyses were performed.Results (1) 1821 residents were surveyed including 844 male and 977 female subjects.The overall prevalence of MS was 8.68％ and the overall prevalence of central obesity was 15.87％.Both prevalence rates of the two diseases appeared to be lower in males than in females(MS:3.32％ vs.13.31％; center obesity:5.57％ vs.24.77％,all P＜0.001 ).(2) The overall positive rate of clustering on other MS risk variable was 36.02％,with 34.12％ in males and 37.67％ in females.Comparing the subjects who did not have central obesity,those subjects wth central obesity had higher positive rate in other MS risk variables.(3) Data from analysis of covariance showed that the level of waist circumference appeared an upward trend along with the count of other MS risk variables (all P＜0.001 ).(4) Data from multivariable logistic regression analysis showed that central obesity was a risk factor on clustering of other MS risk variables.Conclusion Control the level of waist circumference among normal body mass index was an effective method in preventing metabolic syndrome and cardiovascular disease in adults.