Effect of H. Pylori on Fibrinogen Level among Sudanese Patients at Khsartoum State

Background: Helicobacter pylori (H. pylori) is a gram-negative, spiral shaped pathogenic bacterium that specifically colonizes the gastric epithelium causing chronic gastritis, peptic ulcer disease, and/or gastric malignancy.Aim: To assess the effect of H. pylorion fibrinogen level of Sudanese patients with diabetes millets (D.M) living in Khartoum state.Subjects and Methods: This was case control study conducted among Sudanese diabetic patients during the period from May 2018 to July 2021. A total of 181 diabetics patients are involved in this study. Citrated blood and stool samples were collected from each participant. All stool samples were tested for the presence of H. pylori antigen by using commercially available H. pylori antigen detection card. Based on the result examination for H. pylorithe study population are sub grouped in two groups one group 124 of cases with Positive H. pylori antigen and another group 57 of controls with negativeH. pylori infection. Both groups were assessed for the fibrinogen level. Data was gathered and analyzed by using SPSS version 20.Results: Our results revealed that cases have slightly higher values of fibrinogen levels 326.29± 89.99 mg/dl compared to 309.47± 90.82 mg/dl for control group. However, the statistical analysis indicate that the difference was remain insignificant with P-value of 0.246. Among cases group gender concerned the fibrinogen concentration mean in the plasma of male 336.2±98.5 mg/dl was higher than female 311.1±73.4 mg/dl.Conclusion:they were insignificant association between fibrinogen level and presence of H. pyloriinfection among Sudanese diabetic patients. gender concerned the fibrinogen concentration in the plasma in H. pylori among males showed higher levels than females.

Effect of H. pyloriamong Diabetic Patients Living in Khartoum State, Sudan

Background:Studies suggest an association between Helicobacter pylori (H. pylori)infection and extra gastrointestinal disease. Limited studies provided conflicting results on the association between H. pyloriinfection and diabetes. The present study was aimed at examining the association between H. pyloriinfection and diabetes among Sudanese patients.Methods:This was case control study conducted among Sudanese diabetic patients during the period fromMay 2018 to July 2021. A total of 181 diabetics patients are involved in this study. Blood, stool samples were collected from each participant. All stool samples were tested for the presence of H. pylori antigen by using commercially available H. pyloriantigen detection card. Based on the result examination for H. pylori the study population are sub grouped in two groups one group 124 of cases with Positive H. pyloriantigen and another group 57 of controls with negative H. pylori infection. Both groupswere assessed for the level of fasting blood glucose. Data was gathered and analyzed by using SPSS version 20.Results: among cases group the mean of fasting blood glucose was 201.94± 90.45 mg/dl compared to 199.40± 97.83 mg/dl among control group. The statistical analysis was showed insignificant difference between cases and controls in the level of fasting blood glucose with P-value of 0.864 . In addition, among cases group the mean of male’s blood glucose 213.0±91.52 mg/dl was higher than females blood glucose level 185.0 ±87.0 mg/dl.Conclusion: They were insignificant association between blood glucose level and H. pylori infection among diabetes patents, However, the subgroup analysis suggested that H. pylori infection was possibly associated with increased risk of diabetes among males. Future cohort studies are needed to verify this association in females and to address possible implication in the prevention of diabetes

Dengue hemorrhagic fever outbreak in children in Port Sudan

Dengue fever [DF]/dengue hemorrhagic fever [DHF] has emerged as a global public health problem with countries in Asia and the Pacific sharing more than 70% of the disease burden. In 2004-2005 a total of 312 cases admitted to Pediatric and Sea Port Hospitals in Port Sudan were clinically diagnosed as DHF. The mortality rate recorded was 3.8% [n = 12]. Of the cases 73.4% were patients 5-15 years of age. A total of 91.2% of cases were admitted during May and June 2005 with 49.4% residing in the eastern region of Port Sudan. Dengue shock syndrome was observed in 37 of 312 [11.9%]. All patients had thrombocytopenia with platelets count ranged from <100,000 to <150,000 cell/mm3. Of the 40 sera tested using RAPID-cassette test in the Khartoum Central Public Health Lab, 36 [90%] were dengue IgM positive. A subset of these sera [n = 23] were sent to NAMRU-3 and confirmed by IgM-capture ELISA; 9 of 23 were PCR positive for dengue serotype 3. Published by Elsevier Limited on behalf of King Saud Bin Abdulaziz University for Health Sciences. All rights reserved