RESUMO
Thyroid Cancer is a disease, which becomes a cause of death in developing countries. The aim of this study is to investigate all the possible risk factors of thyroid cancer in Pakistan. This study was consisting of 320 individuals, including 160 cases and 160 controls. These subjects were interviewed from the INMOL hospital and Sheikh Zayed Hospital, Lahore. The information was collected regarding the characteristics like age, gender, family history of thyroid cancer, use of iodine-diet, radiation therapy, etc. Descriptive and inferential statistics were used to explore the risk factors of the thyroid cancer. Odds ratio and 95% confidence interval [CI] were computed by using logistic regression model. The result showed that the odds ratio and 95% CI for family history of cancer are 2.222 and [1.281-3.853], for use of iodine diet are 2.619 and [1.492-4.596], for acromegaly disease are 1.947 and [1.123-3.374], for oxidative stress are 6.229 and [3.473-11.172], for red meat are 2.601 and [1.421-4.762], for fast food are 3.177 and [1.745-5.785], for fried food are 2.357 and [1.268-4.382], for the use of fats are 2.531 and [1.265-5.064] and for sea food are 2.050 and [1.127-3.729], respectively. It can be concluded that oxidative stress has 6 times high risk of thyroid cancer with the odd ratio 6.229 and CI [3.473, 11.172]. Moreover, fast food, the use of iodine diet, red meat and the seafood are also increased the risk factor of thyroid cancer
RESUMO
Objectives: To determine correlation between blood levels of high sensitivity c-reactive protein [Hs CRP] and severity of coronary artery disease [CAD] on coronary angiography measured through Gensini scoring system
Study type, settings and duration: The descriptive case study was conducted at Rawalpindi institute of cardiology. The duration of study was six month
Patients and Methods: Adult patients of both genders between age 25 to 60 years visiting to outpatient department of the institute and registered for coronary angiogram were included. From each of the enrolled patient about 5cc venos blood sample was collected and Hs-CRP was performed. Severity was measured through Gensini score after coronary angiography. Angiographic Gensini scores were correlated with Hs-CRP using Pearson's correlation [2-tailed]. Value of < 0.05 was considered statistically significant
Results: Total 87 patients fulfilling the inclusion criteria were enrolled among them 81.6% [n=71] were males and 18.4% [n=16] were females. The correlation coefficient was found to be 0.043, implying that there is negligible relationship between Hs-CRP and Gensini scores at p= 0.696
Conclusion: There is no significant correlation between Hs-CRP and severity of CAD measured through Gensini scores on coronary angiography