Comparison of corneal endothelial cell density in patients of pseudoexfoliation syndrome with normal population

Objective: To compare the corneal endothelial cell density in patients of Pseudoexfoliation syndrome [PXS] with normal healthy controls. Study Design: Cross sectional comparative. Place and Duration of Study: This study was carried out at Armed Forces Institute of Ophthalmology, Rawalpindi from Mar 2016 to Jan 2017

Patients and Methods: Patients of PXS and healthy subjects of both genders between ages of 40 and 50 years, with best corrected visual acuity of 6/6 on snellen visual acuity chart were included in the study. All the participants including controls and PXS patients were subjected to ophthalmic clinical examination including corrected distance visual acuity, slit lamp examination by the single trainee researcher to exclude bias. Participants in both groups were evaluated for corneal endothelial cell density [ECD] by using non-contact, TOPCON SP 3000P Specular microscope. Sampling bias was eliminated by analyzing 100 cells in the center of each specular microscope photograph and mean of three readings was analyzed

Results: Both the groups were similar with respect to gender and age. In our study sample there were 29 [58%] males in PXS group and 24 [48%] males in control group with no statistical significant [p-value > 0.05] difference between gender distributions of both groups. The mean age of the PXS group was 46.34 +/- 2.932 years, and in control group was 45.54 +/- 2.887 years [p-value >0.05]. The mean value of ECD was found to be 2021.548 +/- 528.142 cells/mm2 in PXS patients and the mean value of ECD in healthy subjects was noted to be 2772.692 +/- 383.395 cells/mm2, showing significantly lower ECD in PXS cases. Similarly, significantly higher number of cases 22 [44%] had CED <2000 in PXS as compared to normal healthy subjects

Conclusion: Corneal endothelial cell density decreases in patients of pseudoexfoliation syndrome and this must be considered while planning any intraocular surgery including cataract extraction

effective combined therapy of meglumine antimoniate and co-trimoxazole for cutaneous leishmaniasis: a study in Quetta City

Objective: To evaluate the efficacy of combined therapy of meglumine antimoniate and co-trimoxazole in cutaneous leishmaniasis [CL]

Methods: 180 patients with active lesions of CL, confirmed by fine needle aspiration cytology [FNAC] were treated with combined therapy of meglumine antimoniate [Glucantime] and co-trimoxazole [Septran] for 20 days

Results: Out of 180 patients, 160 [88.9%] were cured. A few patients reported nausea, vomiting, glossitis, skin rashes and folate deficiency

Conclusion: The combined therapy of meglumine antimoniate [Glucantime] and co-trimoxazole [Septran] is more effective than the previously reported combined therapies

Audit of five years of burn ICU in BMC hospital Quetta

Burns are series form of trauma with grave consequences for the patient and Family, with high morbidity and mortality. Since the establishment of burns ward at Bolan Medical College and Complex Hospital Quetta in 2002, we have been Receiving and managing a great variety of patients with burns from Kerosene oil, Petrol, gas, fire, scalds, chemical and Electric bums, Patients were received from With in [balochistan and sindh] and outside Afghnistan and Iran [Irani Balochistan] and as victims of war on terror from the region as a results on going war. An audit of our patients received from 2004 to 2008 has been presented which Consists of patients out of which 58% were male and 42% were female, Major Pathogens isolated were staphylococcus aurous [MRSA] and pseudomonas. Indicates of infection was high in patients with longer stay and extensive burns out Come of admit patients is also mentioned

Hybrid external fixation in treatment of metaphyseal fractures of long bones of the lower extremity

This study was conducted to evaluate the clinical results of metaphyseal fractures of tibia and distal femur after operative treatment by Hybrid External Fixators. A prospective descriptive study from 2004 to2008, conducted in Orthopaedic unit I, Bolan Medical Complex Hospital, Quetta. We have prospectively analyzed the results of Hybrid external fixation in the management of metaphyseal fractures tibia and femur in 21 patients [17 open and 4 closed fractures]. The mean age of the patient was 36.5 years. Age range was 14 yeas to 60 years. Eighteen patients were males and 3 were females. In 19 patients hybrid fixation was the primary procedures while 2 patients were initially dealt by local bone setters. Four patients subsequently required surgeries such as bone grafting and soft tissue cover. The mean follow up our patients was 14.8 months [5-24 months]. We achieved excellent results in 10 fractures, good results in 4 fractures, fair in 4 fractures and poor results in 3 fractures. Bony union was achieved in 18 of the fractures. Hybrid external fixation is an effective and useful treatment modality in the management of fractures close to joints in case of tibia, providing excellent to good results. In ease of distal femur it proved to be less effective. It combines the advantage of both Ilizarov and A.O. external fixators. It is minimally invasive, safe, modular and yet efficient in promoting massive new proliferative callus formation at the fracture site

Plate augmentation for femoral non-union after intramedullary nailing

This study was conducted to evaluate the clinical results of femoral non-union after intramedullary nailing treated by plate augmentation with or without autogenous bone grafting. a prospective descriptive study from 2004 to 2007, conducted in Orthopaedic unit I, Bolan Medical Complex Hospital, Quetta. We have prospectively analyzed the results of augmentation plate fixation in the treatment of femoral non-union after Intramedullary nailing in 36 patients. The mean age of the patient was3 1.4 years, 34 patients were males' and 2 were females. Age range of the patients was 22 years to 58 years. In 7 patients showing atrophic non-unions, autogenous bone grafting was done. The mean follow up of our patients was 1 year [4-18 months] post-operatively. Solid union was achieved in 34 femoral non-unions, [94.4% union rate]. Two cases showed non-union, requiring further surgery. Plate augmentation is a useful treatment option in the management of non-union of femoral shaft fractures after intramedullary nailing