Moxifloxacin in the treatment of uncomplicated enteric fever

Many drugs have been used for the treatment of enteric fever. Moxifloxacin is a newer fluoroquinolone antibiotic also said to be effective against Salmonella typhi. In order to evaluate its effectiveness in our population, suspected typhoid patients were randomly selected from the OPD's of JPMC, Department of Medicine and was subjected to blood culture. 40 blood culture positive patients were given Tablet. Moxifloxacin in a dose of 400 mg per day for 10 days. Patients were observed for settlement of fever and / or any adverse effect during this period. Their CBC, ALT and creatinine levels were 14, 4 days after the cessation of treatment. Fever settled in all patients between days 5 to 6. Blood cultures were negative in all patients after treatment. It was concluded that Moxifloxacin was effective in treating cases of enteric fever

Evaluation of anti A60 IgM for the diagnosis of tuberculosis with ELISA method

Evaluation of Anti Tuberculous IgM antibodies for rapid diagnosis of both pulmonary and extra-pulmonary tuberculosis. ELISA assay based on mycobacterial antigen A-60 [Anda Biologicals, France] was used on the sera obtained from 69 cases of Tuberculosis and 136 controls in the population of Karachi, Pakistan. Of 136 controls only 21.3% were positive for IgM antibodies and showing 78.7% specificity. A very high sensitivity 72.2% was seen in sputum positive active pulmonary tuberculosis. Relatively low 56.2% sero positivity was seen in cases of sputum negative active pulmonary tuberculosis compared to those of sputum positive pulmonary tuberculosis. In cases of extra pulmonary tuberculosis 57.8% sensitivity was observed. In cases of healed tuberculosis only 18.7% were found positive for IgM. The estimation value of IgM against A-60 for tuberculosis and the controls the global sensitivity of 62.2% and specificity of 78.7% was found when IgM estimation was taken into account

Evaluation of the effectiveness of azithromycin in the treatment of uncomplicated enteric fever in local population

Many drugs have been used for the treatment of enteric fever. Azithromycin is a newer macrolide antibiotic also said to be effective against Salmonella typhi. In order to evaluate its effectiveness in our population, suspected typhoid patients were randomly selected from the OPD's of JPMC, Department of Medicine and were subjected to blood culture. 40 blood culture positive patients were given capsule Azthromycin in a dose of 500 mg per day for 10 days. Patients were observed for settlement of fever and/or any adverse effect during this period. Their CBC, ALT and creatinine levels were measured before the start of treatment. They were again subjected to blood culture on day 14, 4 days after the cessation of treatment. Fever settled in all patients between days 4 to 5. Blood cultures were negative in all patients after treatment. It was concluded that Azithromycin was effective in treating cases of enteric fever