RESUMO
Objective: To evaluate the correlation between Central Corneal Thickness [CCT] and Visual Field [VF] defect parameters like Mean Deviation [MD] and Pattern Standard Deviation [PSD], Cup-to-Disc Ratio [CDR] and Retinal Nerve Fibre Layer Thickness [RNFL-T] in Primary Open-Angle Glaucoma [POAG] patients
Methods: This cross sectional study was conducted at Armed Forces Institute of Ophthalmology [AFIO], Rawalpindi from September 2015 to September 2016. Sixty eyes of 30 patients with diagnosed POAG were analysed. Correlation of CCT with other variables was studied
Results: Mean age of study population was 43.13 +/- 7.54 years. Out of 30 patients, 19 [63.33%] were males and 11 [36.67%] were females. Mean CCT, MD, PSD, CDR and RNFL-T of study population was 528.57 +/- 25.47microm, -9.11 +/- 3.07, 6.93 +/- 2.73, 0.63 +/- 0.13 and 77.79 +/- 10.44microm respectively. There was significant correlation of CCT with MD, PSD and CDR [r=-0.52, p<0.001; r=-0.59, p<0.001; r=-0.41, p=0.001 respectively]. The correlation of CCT with RNFL-T was not statistically significant [r=-0.14, p=0.284]
Conclusion: Central corneal thickness had significant correlation with visual field parameters like mean deviation and pattern standard deviation, as well as with cup-to-disc ratio. However, central corneal thickness had no significant relationship with retinal nerve fibre layer thickness
RESUMO
Objective: To determine the efficacy of topical Nepafenac [0.1%], administered post-operatively in prevention of Macular Edema [ME], after cataract surgery in patients with Non-Proliferative Diabetic Retinopathy [NPDR]
Methods: This randomized control trial was conducted at Armed Forces Institute of Ophthalmology [AFIO], Rawalpindi from Sep 2015 to Sep 2016. Sixty eyes of 60 patients with NPDR underwent phacoemulsification with intraocular lens implantation. Group 1 received 0.1% Nepafenac, 8-hourly, in operated eye after cataract surgery for three months, along with routine post-operative medications. Group-2 received only routine post-operative medications. ME was defined as increase in Central Macular Thickness [CMT] of >10% from pre-operative baseline, measured using spectral domain optical coherence tomography
Results: Mean age of study population was 60.97 +/- 4.91 years. Out of 60 patients, 34 [56.7%] were males and 24 [43.3%] were females. Mean pre-operative CMT, 3 months post-operative CMT, mean change in CMT and mean frequency change in CMT of Group-1 was 226.5 +/- 10.86microm, 228.83 +/- 14.56 microm, 2.33 +/- 10.45 microm and 1.05% respectively. Mean pre-operative CMT, three months post-operative CMT, mean change in CMT and mean frequency change in CMT in Group-2 was 223.93 +/- 11.69microm, 236.17 +/- 16.16 microm, 12.23 +/- 12.40microm and 5.51% respectively. ME was observed in one patient [3.3%] in Group-1, and seven patients [23.3%] in Group 2. The difference of mean change in CMT and frequency change in CMT between groups was statistically significant [p<0.05]
Conclusion: 0.1% topical Nepafenac is effective in prevention of macular edema after cataract surgery in patients with non-proliferative diabetic retinopathy [NPDR]