RESUMO
To investigate the effect of erythropoietin on cellular proliferation in SCC-25, TR146 and FIBS cells lines. This observational study was carried out at Department of Oral Pathology Barts and the London Queen Mary School of Medicine and Dentistry Queen Mary, University of London in tye year 2004-2005. This study focuses on the effects of Erythropoietin on 3 cell lines [SCC-25, TR146 and FIBS] when applied for 24 hours respectively, Methylthiazol tetrazolium [MTT] assay was carried out using a range of erythropoietin concentrations [1, 10, 25 units]. Serum free medium was used as a control. In this study erythropoietir significantly increased the cell proliferation of SCC-25 and FIBS with 1 and 10 unit/ml but had no effect on TR146 cells, While 25 unit erythropoietin showed very little effect in increase cell viability in both SCC-25 and FIBS. This study has confirmed that all the concentration of erythropoietin used had effect on SCC-25 and FIBS cell viability but erythropoietin had no effect on TR146 cell viability