Histopathological pattern of endometrial curettings in cases of abnormal uterine bleeding

To determine the histopathological pattern of endometrial curetting in cases of abnormal uterine bleeding in our setup. Descriptive study. Department of Pathology Peoples Medical College Nawabshah. January 1999 to December 2008. Endometrial curettage of 1209 cases presenting with abnormal uterine bleeding ranging from age groups 20 to over 60 years were studied. The patients were subdivided in to groups according to age and pattern of bleeding. The histopathological diagnosis was made and results were tabulated. 502 [41 .5%]presented with menorrhagia, [32%] with inter menstrual bleeding, 121 [10%] patients with polymenorrhoea and 61 [5.1%] with post menopausal bleeding. The various histological diagnoses included proliferative phase, cystic hyperplasia, adenomatous hyperplasia, endometritis, polyps and endometrial carcinoma. Diagnostic curettage provides help in definite diagnosis and proper treatment and is of importance in postmenopausal bleeding. Endometrial hyperplasia is the commonest lesion in patients with dysfunctional uterine bleeding

Significance of HER-2/neu oncoprotein overexpression in invassive ductal breast cancer

To asses the frequency of HER-2/neu Oncoprotein over expression in invasive ductal breast cancer and correlate it with various prognostic parameters. Comparitive cross-sectional study was carriedout at department of pathology Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi. Seventy two [72] formalin fixed paraffin embedded blocks of diagnosed invasive ductal carcinoma were retrieved and 5 m.m thick sections were cut and stained with H and E for the review of diagnosis and grading. The immunohistochemical staining was done on 4m.m thick sections by using Polyclonal rabbit anti HER-2 ZYMED USA, and ZYMED 2nd generation LAB-SA immunodetection system, to see the HER-/neu over expression. Section containing > 50% of tumor cells exhibiting intense circumferential cell membrane staining scored as positive. Thirty one [31%] positive over expression was observed. A statistically significant result [P<.05] was found between HER-2/neu over-expression and lymph node status and size of tumor. Oncoprotein HER-2/neu over expression is directly related to the lymph node status and size of the tumor. These patients may benefit from a more aggressive therapy like Herceptin and can also be used as a prognostic marker in the follow up of these patients