RESUMO
Abstract: The metals toxic for living being are led, mercury, arsenic, cadmium and cobalt. Arsenic is increasing day by day in underground water and is more toxic for the proliferating tissue in the body as intestine, ovaries, testes etc
Study design: Experimental study
Place and duration: National Institute for health, Islamabad from 2008 to 2014
Methodology: 20 Male albino rats were bought from National Health Institute, Islamabad weighing from 250-300 grams. They were divided in to two groups A and B each having 10 animals. Group A was taken as control and was given 10 ml of distilled water orally in the morning and evening with normal diet for 28 days. Group B was given 10 ml of water with sodium arsenite 5mg/kg of body weight for 28 days with normal diet
Results: The present study showed that there was reduction of body and testicular weight of albino rats given arsenic when compared with control
Conclusion: Arsenite and arsenate compounds are highly toxic to human beings as well as animals. Arsenic induced toxicity might be responsible for regression of testes and reduces the body and testicular weight of albino rats
RESUMO
Objectives: The study was undertaken to investigate whether lead toxicity can reduce the diameter and spermatogenesis of testes of albino rats. If the reduction occurs, with what dose the animals can be protected by vitamin C against lead toxicity. Study Design: Experimental study. Place and Duration of Study: This study was carried out at the Department of Anatomy, PGMI, Lahore from March 2007 to August, 2007. Materials and Methods: In this study, 90 animals [albino rats] were taken from National Health Institute Islamabad. These were divided into five groups. Each group has 18 animals as group A, B, C, D and E. Results: The lead treated animals reduced 16% of diameter in 4 weeks as reported by Harvey. The loss of diameter I and reduction in spermatogenesis was due to lead toxicity. In another study by Biswas and Gosh, the animals gave same results with lead toxicity in 14 days. In this experiment it has proved that lead toxicity reduced the body weight of albino rats and this toxicity can be protected with heavy dose of vitamin C. Conclusion: Vitamin C reduces the toxic effects of lead on diameter of seminiferous tubules and spermatogenesis of rats, which is shown in this study