Assuntos
Animais , Antidepressivos/farmacologia , Bupropiona , Catalepsia/prevenção & controle , Feminino , Haloperidol , Masculino , Morfina , Propiofenonas/farmacologia , RatosRESUMO
The effects of ranitidine (2 mg/kg, po) and phenylbutazone (100 mg/kg po) have been studied in different models of acute and chronic inflammation in rats. Ranitidine showed significant anti-inflammatory activity in the four models used. This observation supports the concept that histamine has a pro-inflammatory role that is mediated via stimulation of H2-receptors.
Assuntos
Doença Aguda , Animais , Anti-Inflamatórios , Artrite/tratamento farmacológico , Artrite Experimental/tratamento farmacológico , Carragenina , Doença Crônica , Feminino , Granuloma/tratamento farmacológico , Inflamação/tratamento farmacológico , Masculino , Peritonite/tratamento farmacológico , Ranitidina/uso terapêutico , Ratos , Ratos Endogâmicos , TerebintinaAssuntos
Adulto , Epinefrina/farmacologia , Feminino , Histamina/farmacologia , Humanos , Masculino , Pirilamina/farmacologia , Ranitidina/farmacologia , Receptores Histamínicos/efeitos dos fármacos , Receptores Histamínicos H1/efeitos dos fármacos , Receptores Histamínicos H2/efeitos dos fármacos , Testes CutâneosAssuntos
Animais , Catarata/fisiopatologia , Cabras , Humanos , Cristalino/fisiopatologia , Preservação de Órgãos/métodos , Coelhos , Ratos , Fatores de TempoRESUMO
Pretreatment with L-histidine precursor of histamine was found to delay the onset, shorten the duration and decrease the intensity of stereotyped behaviour induced by methamphetamine while chlorcylizine a H1 receptor blocker was found not only to potentiate methamphetamine induced sterotyped behaviour but also to block the inhibitory effect of L-histidine on methamphetamine stereotypy. Our results indicate that the central histaminergic system by exerting a modulatory influence on the striatal dopaminergic system may influence the functioning of the extrapyramidal motor system.