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2.
Indian J Physiol Pharmacol ; 1986 Jul-Sep; 30(3): 205-9
Artigo em Inglês | IMSEAR | ID: sea-107436

RESUMO

The effects of ranitidine (2 mg/kg, po) and phenylbutazone (100 mg/kg po) have been studied in different models of acute and chronic inflammation in rats. Ranitidine showed significant anti-inflammatory activity in the four models used. This observation supports the concept that histamine has a pro-inflammatory role that is mediated via stimulation of H2-receptors.


Assuntos
Doença Aguda , Animais , Anti-Inflamatórios , Artrite/tratamento farmacológico , Artrite Experimental/tratamento farmacológico , Carragenina , Doença Crônica , Feminino , Granuloma/tratamento farmacológico , Inflamação/tratamento farmacológico , Masculino , Peritonite/tratamento farmacológico , Ranitidina/uso terapêutico , Ratos , Ratos Endogâmicos , Terebintina
5.
Indian J Physiol Pharmacol ; 1979 Oct-Dec; 23(4): 291-6
Artigo em Inglês | IMSEAR | ID: sea-107114

RESUMO

Pretreatment with L-histidine precursor of histamine was found to delay the onset, shorten the duration and decrease the intensity of stereotyped behaviour induced by methamphetamine while chlorcylizine a H1 receptor blocker was found not only to potentiate methamphetamine induced sterotyped behaviour but also to block the inhibitory effect of L-histidine on methamphetamine stereotypy. Our results indicate that the central histaminergic system by exerting a modulatory influence on the striatal dopaminergic system may influence the functioning of the extrapyramidal motor system.


Assuntos
Animais , Comportamento/efeitos dos fármacos , Relação Dose-Resposta a Droga , Interações Medicamentosas , Histidina/farmacologia , Humanos , Masculino , Metanfetamina/farmacologia , Piperazinas/farmacologia , Ratos , Comportamento Estereotipado/efeitos dos fármacos , Fatores de Tempo
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