RESUMO
Objective: To determine the effect of organophosphate poisoning [OPP] among patients at tertiary healthcare, Pakistan
Methods: This cohort study was conducted over a six-year period [January 2011 to December 2016] of OPP patients admitted to the intensive care unit of Peoples University of Medical and Health Sciences for Women SBA, Hospital Pakistan and their outcome was determined
Results: Total mortality was 17.39% [84 deaths in 483 patients, excluding those referred to Karachi]. Out of these 84 deaths, 65 patients [13.46%] expired due to cardiorespiratory failure, 17 deaths [3.52%] followed due to complication of mechanical ventilation and ICU acquired infection and two deaths [0.41%] occurred due to renal failure. The major cause of poisoning was deliberate self-harm /suicidal intention [93.02%], with gender distribution of female [57.07%] and male [35.95%], followed by unintentional/accidental exposure [6.98%] in males. The intensive supportive treatment, precise and appropriate respiratory care, and adequate amount of atropine and pralidoxime doses are keys to reducing the OPP patient's mortality
Conclusion: Organophosphate poisoning [OPP] intoxication is common in female gender. The easy availability of these harmful compounds has resulted in increased mortality either by accidental exposure or most often by the deliberate suicidal attempt