RESUMO
Effect of repeated (20 days) exposure to picrotoxin (PTX) on rat liver lysosomal function was evaluated by measuring the free and total activities of acid phosphatase, cathepsin D, ribonuclease II (RNAse II) and deoxyribonuclease II (DNAse II). The free activities of the nucleases (both RNAse II and DNAse II) were increased following PTX exposure. The total DNAse II activity was increased by 2.2-fold whereas the total acid phosphatase activity was decreased by 28%. Consequently, the ratios of total activity / free activity were low in the PTX exposed groups, implying loss of membrane integrity. Cathepsin D activity was completely abolished. The results show that repeated exposure to PTX can lead to lysosomal dysfunction in liver.
Assuntos
Fosfatase Ácida/metabolismo , Animais , Catepsina D/metabolismo , Convulsivantes/administração & dosagem , Endodesoxirribonucleases/metabolismo , Exorribonucleases/metabolismo , Injeções Intraperitoneais , Fígado/efeitos dos fármacos , Lisossomos/efeitos dos fármacos , Masculino , Picrotoxina/administração & dosagem , RatosRESUMO
Unusual foreign bodies of the larynx viz. a toy gear, a metallic spring, a safety pin, a piece of stone, lodged in the endolaryngeal region are reported. Radiographic documentation with the rare feature of absence of symptoms inspite of lodgement for long duration is recorded.