Muir Torre syndrome: a case report.

Muir Torre Syndrome (MTS) is a rare syndrome complex of association of multiple sebaceous skin tumors with visceral malignancies. Till date a total of 205 cases have been reported in the world literature and to the best of our knowledge this is the first case report from the Indian subcontinent. Multiple, synchronous and metachronous, tiny sebaceous lesions is a hallmark of MTS along with multiple primary carcinomas at different sites, the commonest being gastro-intestinal tract cancers. The visceral cancers occur at a relatively young age. They are low-grade, non-aggressive and have a good prognosis. Awareness of this rare entity is essential. A case report of a 55-year-old male presenting with multiple sebaceous skin tumors, colonic cancer and positive family history in younger brother is presented.

Isolated tonsillar sarcoidosis: a case report.

Tonsillar sarcoidosis can be seen as a part of generalized sarcoidosis or in isolation. Typical non-caseating granulomas are seen in the biopsy. We present a case of isolated tonsillar sarcoidosis masquerading as chronic tonsillitis in a young female.

Renal oncocytoma with hyaline globules: cytologic diagnosis by guided fine needle aspiration, a case report.

Renal oncocytomas are rare renal parenchymal neoplasms which have a good prognosis. An accurate pre-operative diagnosis by guided fine needle aspiration cytology helps to plan a more conservative surgery. Cytologic findings in a case of renal oncocytoma are presented. Smears showed polygonal or rounded cells in groups and acinar pattern having a well-defined, granular, eosinophilic cytoplasm, and round regular nuclei displaying very little pleomorphism. Intra and extracellular hyaline material staining pink with May Grunwald Giemsa stain were seen. The resected specimen showed the characteristic findings of oncocytoma. Renal oncocytoma has to be distinguished from granular renal cell carcinoma (RCC) and chromophobe cell carcinoma, because of the markedly different prognosis.

Mammary hamartoma: report of two cases including one in a male breast, and review of the literature.

Mammary hamartoma is best viewed as a "breast within a breast" and is most often mistaken for fibroadenoma, phyllodes tumour or lipoma. It shows an abnormal blending of normal breast tissue components and is cured by removal. We present two cases of mammary hamartoma one occurring in a male breast. Although it is true, that all diseases occurring in female breast can also be seen in a male breast, there has been no report of this condition in a male. To the best of our knowledge, this is the first case of mammary hamartoma occurring in a male.

Benign stromal fragments in metastases of squamous cell carcinoma in cytology--a report of two cases.

Benign stromal fragments or extracellular matrix can be seen in aspirates of invasive carcinomas. Although well documented on histology, this feature is rarely observed on fine needle aspirates and can create diagnostic difficulties on smears. Only three such cases have been reported so far. We report two more cases where stromal fragments were seen in association with invasive squamous cell carcinoma (SCC). Two cases of biopsy proved invasive SCC of the cheek and of the larynx presented with metastases to the submandibular salivary gland and to the cervical lymph node respectively. Aspirates of the metastatic sites showed two components: one of SCC and the other benign stroma, both in close approximation with one another. Both patients were treated with radiotherapy. Biopsy of the metastatic sites was not done. Benign stromal fragments can be encountered in aspirates of invasive carcinoma. These may be cellular or myxoid. Since such stromal fragments can also be seen in salivary tumours, adnexal tumours, fibroadenoma and phylloides tumour, their presence should be interpreted in the light of clinical findings of the patient, so that an erroneous diagnosis can be avoided.

Triple approach method for screening of contralateral breast in treated cases of breast cancer.

A prospective study of 50 cases of treated breast cancer was undertaken to evaluate the status of the contralateral breast by combined physical examination, mammographic screening and mammographically directed FNAB (triple approach method). This study was done to assess the frequency of synchronous (cancers that were simultaneously diagnosed with a tumour in ipsilateral breast) or metachronous (those that occurred in contralateral breast subsequent to first cancer and not detected at the time of treatment of first cancer) malignancy and/or presence of preneoplastic lesions in the contralateral breast. Six percent cases had palpable lump in contralateral breast (synchronous or metachronous), 10% of the cases showed mammographic abnormalities. Mammographically directed FNAB showed atypical/suspicious smears in 8% cases and malignancy in 2% cases, of which infiltrating duct carcinoma was the most frequent. In high-risk group patients triple approach method proved to be extremely important screening procedure for early detection of abnormalities in contralateral breast and helps in significantly reducing the morbidity and mortality associated with it.