RESUMO
This work was designed to assess the role of toxoplasmosis in recurrent abortion, 771 women attended the obstetrics and gynecology unit at Benha University Hospital were included in this study. 491 of these women had history of sporadic abortions group I; 230 women had history of recurrent successive abortions group II; and 50 women had normal obstetric history group III. The sera of all women were examined for toxoplasma antibodies IgM and IgG using enzyme linked immunosorbent assay [ELISA]. It was found that 213 [43.3%] women were sero positive in group I; 91 [39.5%] woman were sero positive in group II and 8 [16%] women were seropositive in group III. There was a statistically significant difference between group I and III [p < 0.05]. The difference between group II and III was significant [p < 0.05]. The difference between group I and group II was insignificant. Patients with positive sera in group I and II treated by spriramycin antibiotic in one course, 2 grams per day for 3 weeks. Another serological examination was done one week after treatment. The results showed that out of 183 treated women in group I: 124 [67%] women became seronegative and out of 78 treated women in group II: 55 [69%] women converted to seronegative. Repeated abortion in sero negative women was; out of 61 pregnant women in group I; 9 [14.9%] were aborted and out of 40 pregnant women in group II: 7 [17.5%] were aborted, These data confirm that toxoplasma is a definitive cause for recurrent abortion. Serological screening before and during pregnancy for those women who had recurrent abortion can be helpful in reducing the incidence of recurrent abortion