RESUMO
Objective: To determine the relationship between biochemical recurrence and other histopathological factors in prostate cancer
Study Design: Analytical study
Place and Duration of Study: Pathology and Urology Departments, Izmir Ataturk Training and Research Hospital, between 2001 - 2013
Methodology: 117 cases diagnosed with prostatic adenocarcinoma and treated by radical prostatectomy were reviewed retrospectively for histopathological features; whereas, other prognostic findings were noted. PSA levels and many other histopathological parameters were assessed in order to put forth their effect on biochemical recurrence
Results: PSA level [p<0.001], tumor volume [p<0.001], Gleason score [p<0.001], extraprostatic extension [p<0.001], perineural invasion [p<0.001], ganglion involvement [p=0.040], vascular invasion [p<0.001], positive surgical margins [p<0.001], presence of tertiary pattern [p=0.004] and the involvement of the seminal vesicles [p<0.001] were found to be statistically related to the pathological stage. Age, perineural invasion, high grade tertiary pattern, intraluminal mucin, collagenous micronodules and foamy cytoplasmic changes were unrelated to recurrence
Conclusion: Histopathological features can be helpful in predicting prognosis in prostatic adenocarcinomas. However some of the histopathological factors such as intraluminal mucin and foamy cytoplasmic changes may not reflect high recurrence
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Recidiva , Adenocarcinoma , Bioquímica , Prostatectomia , Antígeno Prostático Específico , Gradação de TumoresRESUMO
Arsenic, a naturally occurring metal, is best known as a poison and can generate both acute and chronic toxicity. Exposure can occur through air, water, soil, and food. Chronic arsenic toxicity is usually asymptomatic and the first sign may be cutaneous findings. Arsenic keratosis is a precancerous lesion related to chronic arsenism. Non-Hodgkin's lymphoma [NHL] is a T or B cell malignancy usually originating from lymph nodes and fewer in every other organ.We report a concomitant occurrence of arsenic keratosis and NHL in a Caucasian man.To our knowledge, this is the first such reported case