Effect of chronic noise stress on mantle zone of lymphoid follicle of splenic tissue in albino rats

Noise is an ever growing problem in modern society. Apart from its effect on hearing, behavior, and mood it also has a potent effect on immune system. Therefore the present study was designed to asses' effect of chronic noise stress on mantle zone [MnZ] of lymphoid follicle [LF] of spleen in albino rats. Two groups of twenty rats, each group labeled A and B were used; serving as control [no noise] and noise stress [30 days] respectively. Group B was exposed to noise stress of 100 dB for 30 day [3-4hrs/day]. Animals were sacrificed at the end of study, spleen was removed prepared, sectioned and stained with CD79a. A highly significant decrease in mean no of cell in MnZ of LF was observed [1 5747 +/- 87.82/mm[2]] in noise stressed group when compared with MnZ of control animals [16567 +/- 106/mm[2]]. There was also a highly significant increase in mean perimeter of nuclei observed in MnZ of stressed group [2.74 +/- 0.009pm] when compared with rats of control group [2.68 +/- 0.01microm]. Our study concludes that noise stress induced release of glucocorticoid can significantly decrease number of B lymphocytes in MnZ of LF of spleen in albino rats

Effect of chronic noise stress on mantle zone of lymphoid follicle of splenic tissue in albino rats

Noise is an ever growing problem in modern society. Apart from its effect on hearing, behavior, and mood it also has a potent effect on immune system. Therefore the present study was designed to asses effect of chronic noise stress on mantle zone [MnZ] of lymphoid follicle [LF] of spleen in albino rats. Two groups of twenty rats, each group labeled A and B were used; serving as control [no noise] and noise stress [30 days] respectively. Group B was exposed to noise stress of 100 dB for 30 day [3-4hrs/day]. Animals were sacrificed at the end of study, spleen was removed prepared, sectioned and stained with CD79a. A highly significant decrease in mean no of cell in MnZ of LF was observed [15747 +/- 87.82/mm[2]] in noise stressed group when compared with MnZ of control animals [16567 +/- 106/mm[2]]. There was also a highly significant increase in mean perimeter of nuclei observed in MnZ of stressed group [2.74 +/- 0.009microm] when compared with rats of control group [2.68 +/- 0.01microm]. Our study concludes that noise stress induced release of glucocorticoid can significantly decrease number of B lymphocytes in MnZ of LF of spleen in albino rats

Relationship between smoking and serum ferritin levels

High serum lipid levels, smoking and lack of physical activity are recognized modifiable risk factors for atherosclerosis and coronary heart diseases. Serum ferritin, the stored form of iron provides free iron for oxidation of lipids. It is being investigated as a risk factor for cardiovascular and coronary heart diseases. To find out the relationship between modifiable risk factors serum ferritin and smoking. Material and 38 smokers and 56 nonsmokers, male aged 20 to 66 were selected by convenient method. Smokers were divided in three groups according to smoking strength. Serum ferritin was done by ELISA 1-step sandwich assay. Sample of blood was collected after 14 hours fasting and abstinence of smoking. Serum stored at 20°C for future analysis. Result: Mean serum ferritin in non-smokers was found to be 154 +/- 15.11 ng/ml and in smokers 237.7 +/- 39.89ng/ml, which is highly significant [P< 0.009]. Results were evaluated by SPSS 7.5 software. Smoking contains free radicals that result in oxidative stress, which increases ferritin synthesis

Relationship between physical activity and serum ferritin levels

Atherosclerosis, one of the most important events, is responsible for most of the coronary heart diseases and other cardiovascular diseases. Unfavorable lipid profile, smoking and lack of physical activity are well known risk factors. Serum ferritin, the stored form iron, provides free iron for lipidperoxidation and formation of foam cells of atheroma, is currently being listed as a new modifiable risk factor. To find out any relationship between serum ferritin and physical activity. Material And 45 physically active and 49 non-active, male aged 18 to 65 were selected by convenient sampling. Physically active subjects were divided into two groups, maximally active and moderately active. Blood sample was collected after 14 hours fasting and abstinence of smoking for the detection of serum ferritin by ELISA 1-step sandwich assay. The serum ferritin in physically non active subjects was found to be 205.5 +/- 18.2 ng/ml and in active subjects 168.4 +/- 26.56ng/ml which is weakly negative and non significant [P<0.246]. Became highly significant [P<0.003] when confounders were added. Results were evaluated on SPSS 7.5 Physical activity decreases the serum ferritin. Moderate physical activities are more important in lowering of serum ferritin than heavy