Are treatment guides and rational druguse policies adequately exploited incombating respiratory system diseases?

The aim of the present study was to increase awareness regardingthe rational use of medicines. The data were obtained via the Material ResourcesManagement System Module of the Ministry of Health. For the appropriatenessof treatments, the Global Initiative for Asthma, the Global Initiative for ChronicObstructive Lung Disease, and the guidelines for the rational use of medicines wereused. We also investigated whether any de-escalation method or physical exercisewas performed. Statistical analyses were performed using descriptive statistics todetermine the mean, standard deviation, and frequency. The results showed thathealthcare providers ignored potential drug reactions or adverse interactions, and reflecting the lack of adherence to the current treatment guides, 35.8% irrational useof medicines was recorded. Thus, de-escalation methods should be used to decreasecosts or narrow the antibiotic spectrum, antibiotic selection should consider the resis-tance patterns, culturing methods should be analyzed, and monotherapy should bepreferred over combination treatments

Are the leading drugs against Staphylococcus aureus really toxic to cartilage?

Many studies have shown that the toxic effects of local antibiotics on bone and cartilage limit orthopedic surgeons. In this study, we evaluated three antibacterial agents used locally to treat highly mortal and morbid diseases in the field of orthopedics, such as septic arthritis. Are vancomycin, teicoplanin, and line-zolid, which are archenemies of Staphylococcus aureus, really toxic to chondrocytes? The purpose of the study was to investigate the effects of antibiotics, which are used against S. aureus, on human chondrocytes in vitro

Primary cell cultures obtained from gonarthrosis patients were divided into two main groups. One of these groups was designated as the control chondrocyte culture. The other group was divided into three subgroups, and each group was exposed to vancomycin, teicoplanin, or linezolid. Cell culture samples were characterized by immunophenotyping following incubation with the three different antibiotics. Before and after the agents were administered, the cultures were subjected to inverted and environmental scanning electron microscopy. The number of live cells and the proliferation rate were monitored with the MTT-assay. We found that vancomycin, teicoplanin, and linezolid do not have chondrotoxic effects

Vancomycin, teicoplanin, and linezolid had no chondrotoxic activity during in vitro culture, which supports the argument that these agents can safely be used in orthopedic surgery, especially against methicillin-resistant S. aureus agents