A Case of Solitary Trichoepithelioma on the Toe / 대한피부과학회지

Trichoepithelioma (TE) is a benign lesion that arises from hair follicles. Solitary TE occurs mainly on the face in young adults. Various previous reports have described the localization of this disorder, but there have been no reported cases with presentation on the toe. Histopathologically, TE shares characteristic features with basal cell carcinoma (BCC), so immunohistochemical stains are required for the differential diagnosis. Therefore, we report the first case of TE occurring on the toe, confirmed with immunohistochemial differentiation.

Effects of Gamma-Linolenic Acid for the Treatment of Acne Vulgaris Treated with Isotretinoin / 대한피부과학회지

BACKGROUND: Oral isotretinoin is an effective treatment modality for acne, but this agent may cause dryness of the skin and mucous membrane. Gamma-linolenic acid (GLA) has been known to improve skin moisture and reduce transepidermal water loss (TEWL). It is also known to have anti-inflammatory effects and to inhibit 5-alpha reductase. OBJECTIVE: This study was performed to evaluate the clinical efficacy of GLA in the prevention of xerosis and improvement of acne lesions after concomitant administration of isotretinoin. METHODS: In this prospective study, 102 Korean acne patients were enrolled and randomized to receive isotretinoin either with or without GLA for 12 weeks. Comparing evaluations included skin hydration, TEWL, visual analogue scale (VAS) score for dryness of the lips and skin, number of acne lesions such as comedos, papules, and pustules, Korean acne grading system (KAGS) grade, and patient satisfaction regarding treatment. RESULTS: The decrease of skin hydration and increase of the TEWL of the lips and cheek were less definite in the experimental group than those of the control group. VAS score for dryness of the lips and skin was significantly lower in the experimental group compared with the control group. The number of acne lesions decreased in both groups; only the numbers of papules were different between the two groups. The decrease of the KAGS grade was more definite in the experimental group than that in the control group. CONCLUSION: This study suggests that GLA could be used effectively for the improvement of acne lesions as well as for the prevention of xerosis.

Granular Cell Tumor on the Sole of a Child / 대한피부과학회지

No abstract available.

Lupus Erythematosus Profundus Associated with Kikuchi's Disease / 대한피부과학회지

Kikuchi's disease (KD), histiocytic necrotizing lymphadenitis, is a rare self-limited lymphadenopathy, which usually affects young women. KD has been reported to precede, coexist with or follow the diagnosis of other entities, such as systemic lupus erythematosus (SLE), adult-onset Still's disease, Hashimoto's disease, and viral infections. In a few cases, KD is associated with cutaneous lupus erythematosus (CLE), without systemic involvement. Herein, we report the first Korean case of KD associated with lupus erythematous profundus in a 9-year-old boy.

Halo Seborrheic Keratosis in a Patient with Vitiligo / 대한피부과학회지

Depigmented halos surrounding cutaneous lesions have been the common description of many diseases, including benign melanocytic nevus, acquired blue nevi, malignant melanoma and neurofibromatosis. To the best of our knowledge, a halo around seborrheic keratosis has not been reported in the Korean dermatologic literature, and only two cases have been described abroad. Though vitiligo is known to be frequently associated with this halo phenomenon, the exact etiopathogenesis of vitiligo and the halo phenomenon is still unknown. Herein, we report on a case of halo seborrheic keratosis in a patient with vitiligo.

Successful Treatment of Cutaneous Lesions of Dermatomyositis with Topical Pimecrolimus

Dermatomyositis (DM) is an idiopathic inflammatory process characterized by proximal muscle weakness and cutaneous lesions, such as the Gottron's sign, heliotrope rash, and erythematous photosensitive rash. Administration of systemic agents for the treatment of underlying systemic diseases leads to remission of the cutaneous lesions in many cases. However, cutaneous lesions may remain refractory to treatment. Pimecrolimus is a calcineurin inhibitor with combined anti-inflammatory and immunomodulatory activity. It has high affinity to the skin and low permeation potential, even in patients with acute skin inflammation and in those undergoing post-topical corticosteroid therapy. We herein report two DM patients whose cutaneous lesions were refractory to conventional treatment but showed dramatic response to topical pimecrolimus. The clinical outcomes suggest that topical pimecrolimus may be a good therapeutic alternative for the management of the cutaneous lesions of DM.