A Case of Coccidioidomycosis / 대한피부과학회지

A case of systemic coccidioidomycosis with cutaneous lesions has been found in Dec. 1974, for the first time in Korea, which is proved through cutaneous biopsy .and mycologic culture from skin lesion. The patient was 57-year-old Korean male. Skin lesions on left extremities showed several skin colored or ligbt brownish papules and surrounding circular erythematous scaly patches with slightly elevated borders. The patient was also found to have moderate diabetes mellitus, hypokalemia and resultant neuropathy. Histopathology revealed granulomatous lesions in the upper dermis, and numerous spherules both inside and outside of giant cells. Mycologic culture from grind skin specimen on Sabourauds glulose agar showed snow-white colony and ather typical arthrospores. Ampbotericin B intravenous injection was started and continued for 16 days. During a,dministration of the drug, side effects consisting of chills, fever, headache, chest pain and dyspnea developed. Therefore, further administration of the drug could not be done. During tbe several months following last discharge from the hospital, the patient has been, with no further specific therapy, in relatively good general condition, and developed no new lesions. The old papules have diminished in size, but did not disappear.

A Case of Lupus Vulgaris ASsociated with Scrofuloderma / 대한피부과학회지

A case of Lupus vulgaris associated with scrofuloderma in a 11 year old girl is reported. The girl presented painless swellings, the left being more severe, on her both cheeks. A red, elevated, about 3 x 5 cm in size, partly eroded plaques is seen on her left cheek. On diascopy couple of so called apple jelly nodes are found within the plaque. A long linear red, scar like lesion is also found on her dlavicular area. Submandiblar lymph nodes are enlarged and hard. On right submandibular region there were two finger tip sized dome shaped red swellings which are connected with hard enlarged lymph nodes by cord like strings. The biopsy from left cheek disclosed typical picture of lupus vulgaris. The patient was refered to surgical clinic and was never seen again.

Studies on the effect topically applied Ginsen Saponin on human skin: 1 . Evaluation and Measurement of irritant effect / 대한피부과학회지

No abstract available.

Bleomycin Treatment for Verrucae with Dermo-Jet / 대한피부과학회지

Bleomycin is a glycopetide antibiotic isolated from Streptomyces verticillus which has a wide spectrum of antiturnor and antimicrobial activities and is currently used in treatment of certain neoplasms. Its selective effect on Squamous cell carcinoma was confirmed by Ichikawa(1969) and Ueno(1970). Bleomycin inhibits the synthesis of K)NA in animal cells and has sorne degree of selective toxicity against DNA virus infections. The drug has been reported to be useful in the topical treatment of verrucae by Fujita et al., in 1971. Since then many physicians have been using Bleomycin as topical therapeutic agent on. warts, esecially in Japan. The authors used Bleomycin as topical antiwart agent utilizing needle free syringe ." Dermo-Jet. 29 patients are studied, the clinical and histopathologial cha.nges are followed and reported. The advantages of utilizing Dern:o-Jet compared to that of usual needle syringe method are a) More accurate dosage of the drug can be infiltrated to the lesion, especially in the epidermis. b) Resulting pain is shorter in duration c) The fear, especially of children, created by the introduction of a hypodermic needle is diminished, d) The manipulation of this peculiar syringe n-ay give the patients hypnotic effect. Clinically 3 different ways of regressing processes are observed. 1. Casting off of dried keratinous r.naterial 2. Vesicle or pustule formation 3. Frogressive diminution of the size of warts. Histologic studies are carried out on 24, 48, 72 hours and I week after the injection. 1. The findings of specimens taken 24, 48, 72 hours after the injections include; a) Cells with small elongated deeply basophilic nuclei and eosinophilic cytoplasm whose boundaries are indistinct appeared in some areas of the epidermis. In the lower most layer of the epidermis several rows of small cells with. minute basopbilic nuclei lie in palisade arrangement. b) Loss of basal cell layer c) Necrosis of epidermal cells d) Subepidermal abscess 2. The findings of specimen taken 7 days after the injection are; In the mid part of horny laycr band like collection of yellowish-brown hemorrhage born material and small elongated deeply basophilic nuclei which were observed in l. a) are seen. Directly beneath this area the epidermis showes no basal cell layer and many finger like projectians of rete ridges whir,h is far more in number than normal skin, It is thought that healing process of wart through Bleomycin local injection can be accomplished by 1. The altered epidermal cells reject further wart virus replication and heals by casting off of all altered part of the epidermis. 2. The subepidermal abscess may brings wart to be cast off, 3. The wart virus be destroyed directly by Bleomycin. Bleomycin treatment with Dermo-Jet has a definite place in the management of warts.

A Case of Epidermolytic Hyperkeratosis / 대한피부과학회지

Epidermolytic Hyperkeratosis is a rare variant of ichthyosis, transmitted as autosomal dominant inheritance. A 2-year-old male baby, in whom no hereditary back ground was found, showed typical clinical and histopathological features of Epiderrnolytic Hyperkeratosis. The possibility of occuring the disease without hereditary back grcund, clinical features, and histological characteristics of the disease are discussed.