Transient Myeloproliferative Disorder with Mosaic Down Syndrome: A Case Report / 대한혈액학회지

Individuals with Down syndrome have a high incidence of hematologic diseases such as transient myeloproliferative disorder (TMD) and acute leukemia comparing to the normal children. TMD usually undergoes complete recovery within a few months without any treatment. In Korea, there were several cases of TMD with Down syndrome in the literatures, but no reports of TMD in a phenotypically normal newborn with mosaic Down syndrome. We experienced a case of TMD in a 19- day-old male who was phenotypically normal newborn with mosaic Down syndrome. Specific treatment was withheld, hematologic recovery occurred within one month of diagnosis. We report the case with brief review of literature.