RESUMO
Eighteen mature mice were used and divided into three groups: [1] The 1st group [6 animals] was kept as control. [2] The 2nd group [6 animals] was given daily S.G. doses of stadol for 2 weeks. [3] The 3 rd group [6 animals] was given daily S.G. doses of stadol for 4 weeks. After each period blood samples were collected to test the liver functions. Then the animals were scarificed and their livers were removed and frozen sections were prepared for histochemical study of five enzymes. The significance of the results was discussed. Generally there is increased activity of the hydrolytic enzymes differ. The affection was more severe with prolongation of the period of administration of stadol. Liver functions must be normal before administration