RESUMO
Background: In patients with CKD and diabetes combined, anemia may be relative or absolute. If the serum ferritin is more than or equal to 100ng/ml associated with reduced iron saturation, then it is defined as functional iron deficiency anemia. This type of anemia is very common in patients with CKD. To compare serum iron, TIBC, transferrin saturation and serum ferritin in anemia of chronic renal diseases with healthy controls.Methods: A hospital based comparative study was carried out among 30 known cases of chronic kidney disease with anemia. They were compared with 20 age and sex matched healthy control who were free from chronic kidney disease and anemia. The parameters like serum iron, TIBC, transferrin saturation and serum ferritin were compared between the two groups. Student’s t test and a two tailed p value were calculated and if the p value was less than 0.05, it was taken as statistically significant.Results: It was seen that the mean hemoglobin value was significantly less among CKD patients compared to healthy controls (p<0.05). Serum iron was also significantly less among CKD patients compared to healthy controls (p<0.05). TIBC as significantly high among CKD patients compared to healthy controls (p<0.05). This is because of low hemoglobin and low serum iron in CKD patients but again the transferrin saturation was significantly low among CKD patients compared to healthy controls (p<0.05).Conclusions: Anemia prevalence was very high in CKD patients. Hemoglobin, serum iron and transferrin saturation were significantly low and TIBC was significantly high.
RESUMO
Background: Exposure to nicotine can lead to increased morbidity and mortality among fetus and mothers. The objective was to study the effect of nicotine exposure on the birth weight of the babies.Methods: During the study period of one year, it was possible to recruit the total 144 subjects. 36 were women who were exposed to nicotine as they were bidi rollers. The exposure was confirmed by history. 36 women delivered during the study period and these newborns were included in the present study. Control group were 36 pregnant women who were not exposed to nicotine. They were asked about the exposure history, like anyone in their family is smoking inside the house any time and their occupation. Among these all (36) delivered during the study period and their newborns were included in the present study.Results: Both the groups were comparable in terms of age, hemoglobin, body mass index, gestational age. The mean birth weight of babies in the control group (whose mothers were not exposed) was 3.01kg with a standard deviation of 0.56 compared to mean birth weight of babies in the study group (whose mothers were not exposed) of 2.73kg with a standard deviation of 0.40. This difference in the mean birth weight of babies in the study group and the control group was found to be statistically significant (p<0.05). The mean serum cotinine value in study group mothers and babies was very high compared to zero value in mothers and babies of control group and statistically significant (p<0.05).Conclusions: Maternal nicotine exposure through beedi rolling is associated with reduced birth weight.