Effect of griseofulvin therapy on the central excitatory neurotransmitters in the brain of experimental animals

This study was carried out on 31 rats classified into two groups. The first group [10 animals] was kept as a control while the other group [21 rats] was given griseofulvin 30 mg/kg/day orally for 14 days. Griseofulvin induced a significant increase in the brain serotonin level, while it displayed insignificant alteration in the brain adrenaline and Noradrenalin levels. A decrease in the true cholinesterase activity was found in the brain of animals on griseofulvin therapy. The alteration in the levels of these main excitatory central neurotransmitters may be the underlying causative factor for the occurrence of the various psychic and nervous side effects sometimes observed during griseofulvin therapy in man