[ rare case of crimean-congo hemorrhagic fever]

Crimean- Congo Hemorrhagic fever [CCHF] is a viral disease that transmitted to human by the bite of mature tick vectors, contact with the infectious blood or viraemic tissues during slaughter and hospital contacts. Eighty percent of the cases are sub clinical and the rest of them are presenting with an acute febrile and occasionally hemorrhagic disease. The mortality rate of the fulminate form of this disease is equal to 20% to 50%. It is a Case Report. The patient was an Iranian 55 years-old housekeeper woman who was resident of Qom province. The obtained epidemiologic data showed that this patient had the close contact to fresh animal corpse and their secretions within five to six days before her death. Clinical history of this patient was as follows: sudden onset of symptoms, sever fever, myalgia, diarrhea, bleeding diathesis and anal hemorrhage during hospitalization. The first serum diagnostic test by RT-PCR was positive. Crimean-Congo haemorrhagic fever diagnosis could be considered for the referred patients with acute symptoms suddenly such as high fever with muscle pain, diarrhea and bleeding diathesis

frequency of coagulase negative staphylococci urinary infections with antimicrobial resistance pattern in Rafsanjan

Coagulase negative staphylococci are recognized as the important agents in the urinary infections of young women and elderly men. These agents are resistant to many of the antibiotics. The objective of this study was to find out the frequency and antimicrobial resistance pattern of this organism in urinary infections. This cross sectional study was performed on 1067 patients who were referred to Rafsanjan laboratory due to urinary symptoms. Urine analysis and cultures with [Blood agar, Eosin methylen blue, Hinton Agar], besides Catalase and coagulase assay were done. Coagulase negative staphylococci was isolated from 6% of cultures. Frequency of this infection had no difference between female and male and also between different groups. Based on antibiotic resistance pattern; resistance to Cefalotin was [72.5%], Cotrimoxazole [62.5%], Penicillin [60%], Nitrofurantoin and Gentamycin [55%], Nalidixic acid [52.5%], Oxacillin [47.5%, Cephalexin [45%], Clindamycin [35%], Vancomycin [30%] and Ciprofloxacin [2.5%]. Positive cultures are significant [6%] and recognition of urinary infection due to Coagulase negative staphylococci is very important because misdiagnosis leads to wrong treatment

Therapeutic effects of beta- interferons in patients with multiple sclerosis

beta-Interferons have been reported as effective medicine in the treatment of Multiple Sclerosis [MS], but due to their cost and side effects, the duration of therapy is controversial. The current study aimed to reveal the rate of recurrence according to the duration of medication among the patients receiving beta-Interferons in a 2 year period in Rafsanjan city. In this cohort study, patients who had relapsing-remiting MS for at least 2 years and had been receiving B-Interferon for at least 3 months were followed. The patients were given a questionaire containing their demographic information, recurrence rate and duration of treatment with beta- Interferon. Sixty three point six percent had no exacerbation in the group receiving medication for 3-6 months, while 38.1% in the 6 months-1 year group, and 41.7% in the 1 year group had no exacerbation. There was no significant relationship between the duration of receiving medicaton and the number of recurrence rate. Recurrence rate in the first and second group [< 12 months therapy] was 0.46% and in the third group [> 12 months therapy] was 0.35%. The results showed no significant relationship between recurrence rate and the duration of beta-Interferon therapy. Longer period of treatment is recommended to assess the therapeutic effects of beta-interferon