Synthesis and antimicrobial activity of novel monosaccharide [quinolin-4-yI] hydrazones, oxadiazoles, thiazolidinones and pyrazoles

Several quinoline derivatives appear to be of interest due to their biological and pharmacological activities. The present work deals with the synthesis of some new quinolines incorporated with monosaccharidehydrazone, oxadiazole, thiazolidinone, and/or pyrazole moieties at 4- position, starting with 2-[6-bromo-2-methylquinolin-4-yloxy] acetohydrazide [4] as the key intermediate. Some examples of the new compounds showed moderate inhibitory effect on the growth of G+ve, G-ve bacteria, yeast and fungi