Electromyographic study of some cases of anorectal intercourse

In this work, 20 anorecetive intercourse [ARI] cases of both sexes, referred to Cairo Medicolegal Department, ministry of Justice, were examined. They were compared with 10 healthy non-anorecetive subjects. Regarding the characteristics of the studied cases, 30% of males were married compared to 60% of females. Anal penetration was complete in all married cases [males and females], while it was 70% and 60% in unmarried ARI males and females respectively. There were no signs of violence in all married cases as they were cooperative with the other partner. Regarding local examination, in 80% of married female cases the anus was deeply seated compared to 70% in married males. In unmarried female cases, 670% had deeply seated anus compared to 80% form males. Funnel shaped anus was detected in 70% of ARI married female cases and 60% of ARI married male cases. It was 40% in ARI unmarried females and 80% in ARI unmarried males. The analysis of needle electromyography [EMG] mapping of the external anal sphincter of ARI subjects revealed weakness, which ranged from mild to marked at localized sites and sometimes there was generalized weakness at all sites compared to the control healthy cases

Evaluation of the role of calcium channel blockers on treating the cardiac toxicity induced by theophylline overdose in albino rats

Theophylline is currently used to treat various illnesses [asthma, syndromes of airway obstructurion, bronchioliolitis in infants, etc]. It has a narrow therapeutic index with resulting higher incidence of toxicity and death. Central nervous system effects and cardiac toxicity manifestations are the main cause of death especially in elderly patients and neonates. Four major theories have been proposed to explain theophylline's harmacologic effects. The most recent one suggested that the drug's action may result direct from chanes in intracellular calcium transport. LSo the aim of our study is to evaluate the role of calcium channel blockers [CCBs] on treating the cardiac toxicity induced by theophylline overdose in albino rats. 35 mature albino rats of both ses were divided to 5 groups [n=7]. The first was injected with saline. Groups 2,3,4 and 5 were injected by 150mg/kg [LD95] of theophyline intraperitoneal. Then groups 3,4 and 5 were injected by therapeutic doses of CCBs [verapamil, diltiazem and nifedipine], respectively. The electgrocardiogram was recorded for all groups, serum creatine phosphokinase [CK], lactate dehydrogenase [LDH], K+ and Na+ were measured and hisopathological examination of the heart had been performed. Results indicate that groups 3,4 [treated with veraamil and deltiazem] shows improvement of the cardiac toxicity induced by theophylline overdose in the form of decrease S-T segment level, decrease of serum CK and LDH [P<0.001] and improvement of histopathological ischemic manifestations of the heart. Group 5 [treated with nifidepine] shows nonsignifidant changes