RESUMO
Background: Visceral adipose tissues secrete several adipocytokines that modulate on their own way the extreme obesity, diabetes, dyslipidemia, atherosclerosis and inflammation. Visfatin is newly identified adipocytokine that is released by visceral adipose tissue. Its levels markedly increase during development of obesity. The aim of this study was to determine the levels of visfatin and its association with dyslipidemia in obese albino mice
Methods: It was a quasi experimental study. Sixty [60] Balb/c strain albino mice were divided into two groups of 30 each. Group I was taken as control non obese mice while Group II animals were fed high fat/high carbohydrate diet. Blood samples were collected to measure Total Cholesterol [TC], Triglycerides [TG], High Density Lipoprotein [HDL-C], Low Density Lipoprotein [LDL-C], Very Low Density Lipoprotein [VLDL-C] and visfatin levels
Results: There was significant correlation among different classes of lipids with increasing visfatin levels in diet induced obese mice [p<0.05]. TC, TG, LDL and VLDL showed significant elevation in serum levels [5.94+/-1.18 mmol/L, 2.92+/-0.15 mmol/L, 3.91+/-0.56 mmol/L, 1.56+/-0.31 mmol/L respectively] against controls [3.1+/-0.40 mmol/L, 1.62+/-0.01 mmol/L, 1.82+/-0.432 mmol/L, 0.60+/-0.13 mmol/L correspondingly]. Pearson's correlation coefficient between rising serum visfatin and various classes of lipids showed strong positive correlation between visfatin and TC, TG, LDL, and VLDL, while negative correlation with serum HDL levels [p<0.05]
Conclusion: Increased serum visfatin levels are strongly associated with obesity and dyslipidemia
RESUMO
Background: The course of chronic kidney disease [CKD] is complicated by dyslipidemia defined as changed plasma lipid levels and abnormalities of lipoproteins associated with early onset of atherosclerotic events. The altered pattern of lipid and lipoproteins metabolism results in rapid progression to end stage renal disease [ESRD] and atherosclerosis. The aim of this study was to see the pattern of dyslipidemia in CKD patients and to evaluate the effects of various sociodemographic variables on patterns of lipids and lipoproteins
Methods: This was a cross- sectional observational study conducted in Ayub Teaching Hospital, Abbottabad. In group-I, 313 patients of CKD were included in the study and 150 subjects with normal renal functions were taken as control. Serum lipid profile was evaluated for both groups. Effects of sociodemographic variables like age, sex, BMI, diabetes, hypertension and duration of renal failure was assessed. Data were analysed using SPSS-17 and p<0.05 was taken as significant
Results: Out of 313 subjects, 144 [46%] were female and 169 [54%] were male. The mean age of the patients was 48.48+/-14.78 years and it was 46.20+14.90 in controls. Most common type of dyslipidemia was hyperlipidemia of low density lipoprotein cholesterol [LDL-C] present in 90% patients. Hypertriglyceridemia was observed in 72% of patients. Low values for high density lipoprotein cholesterol [HDL-C] was observed in 28% of CKD group. Very low density lipoprotein cholesterol [VLDL-C] was found raised in 72% of CKD group. The most frequent dyslipidemia in combination was high LDL-C and high TG [201, 64%]. Eighty-two [26%] of patients had a combination of high triglycerides [TGs] and low HDL-C
Conclusion: Significant dyslipidemia does develop in vast majority of chronic renal failure [CRT] patients. This is an important risk factor associated with early onset of atherosclerosis