comparative study of the protective effect of some antidotes on the pancreas in Paraquat intoxicated rat

This study was conducted on 45 adult albino rats classified into four groups. Pancreatic sections were examined histologically by the routine stain H and E using LM and ultrastructurally by EM. Paraquat [PQ] intoxicated pancreas revealed massive degenerative and necrotic changes affecting both exocrine and endocrine parenchyma. By using Nath, the endocrine parenchyma was saved, while the exocrine one showed focal degenerative changes. On the other hand, deferoxamine [DF] showed a better protection than Nath as antidote for pancreatic PQ toxicity

Ultrastructural changes of linea alba in relation to age, repeated pregnancy and obesity

This study was carried out on 12 married females. They were classified into four equal groups according to three parameters: Age, weight and number of pregnancies. Group 1 was used as a control group, group 2 included multipara, group 3 included obese females and group 4 included old females. Biopsies from the linea alba were taken after abdominal incision during surgical procedure and prepared for ultrastructural examination. The results of this study revealed that the linea alba in multipara and obese females showed ultrastructural changes in the form of wide spaces separating the collagen fibrils, variation in the diameter or the fibrils [most fibrils were thin in multipara and thick in obese]. Numerous fibroblasts were also encountered. On the other hand, in old females, the collagen fibrils appeared aggregated into clumps separated by wide areas. The majority of the fibrils were thick in diameter. Some showed spiny outline and dark stained periphery. Few individual fibrils showed moth-eaten appearance. Fibroblasts were rarely encountered in the examined biopsies whereas fibrocytes and macrophages were numerous