Effect of "Flit"[TM] on the productive profiles and the histopathological changes of internal organs of adult albino rats

This formulated product as composed of the necessary amounts of pyrethroids and the required amount of the Kerosine caused severe, unacceptable pathological developmental changes. Body weight of newborns showed progressive affection of the newly born, of which Kerosine has marked influence. Mother behaviour was studied from quality of nest, post parturient aggressive interest of mother towards their youngsters were found to be significantly affected. Male sexual activity was revealed from weight of testis or accessory organs and semen quality. Kerosine alone induced significant differences. Estrous cycle was affected and regressive activity prolonged whatever the animal is exposed. Number of dead and resorbed foeti was significantly different in Kerosine and the whole compound. Teratogenic affection of the born foeti were clear even with Kerosine alone and absence of accessory elements [thymus gland]. Thus, this formulation is described as being severely hazardous and care should be taken even with the manipulation of Kerosine alone

Insufficiency of kerosine as solvent to pyrethroids [tetramethrih and permethrin] in the formulation of insecticides and its influence on blood parameter in adult albino rats

This investigation involved the effect of Kerosine for long time [288 days in these concentrations] as a stress hazardous influence that caused unfavorable manifestations. The direct effect was on hemobiotic system which was concluded from the MCHC and was more indicated in the females than males and that was more clear in the Neutrophiles / lymphocytic ratios. This investigation showed also the hormonal affection as for the cortisol, testosterone leading to a more hazard insufficiency of the testicular functions. Thus it is clear that this formulation has a damaging effect on the productive system as well as the haemopoetic system affecting the blood initiating cells as revealed from the peripheral blood studies. Thus it is necessary to avoid the production of this formulation due to its direct effect on the blood forming system as well as the hormonal profiles in both male and female in individual animals

Effect of ethanol on thyroid hormones and blood coagulation indices in rats with special reference to the structural changes of liver

The present study was done to evaluate the effect of varying doses [100 and 200 mg/rat/day] of ethanol administration [3 months] on thyroid hormones [T[3] and T[4]] in both male and female rats. Results revealed that both T[3] and T[4] concentrations and T[4] /T[3] ratio were significantly increased in treated rats. The response was a dose-dependent. In addition, there was a significant increase in PT and APTT of both male and female rats. The effect of high dose was more pronounced. Histopathological findings of liver tissues showed foci of lymphocytic infiltration with congestion of blood vessles in rats exposed to low dose while, in those treated with higher dose the change was associated with cytoplasmic vacuolization and necrobiotic changes of some individual hepatocytes, So, it may be hypothesized that ethanol exposure may directly or indirectly influence thyroid function and based on the structural changes observed in alcohol exposed hepatocytes, the functional alterations recorded in some blood coagulation indices [PT and APTT] may be implicated