Preparation and evaluation of controlled release frusemide tablets using gel matrix systems

Controlled release frusemide matrix tablets were prepared using different polymers; namely, xanthan gum [XG], hydroxypropylmethyl cellulose 4000 [HPMC 4000] and sodium carboxymethylcellulose [NaCMC] at different concentrations. The prepared tablets were subjected to in vitro release studies as well as medium penetration and wet/dry weight determinations to elucidate the overall mechanism of drug release from the matrix tablets. The release rate studies showed that the most drug sustainment was obtained from tablets prepared with 10% w/w XG when compared with those prepared with 20% w/w HPMC 4000 or 60% w/w NaCMC. The results of medium penetration and wet/dry weight determinations indicated that the highest liquid uptake and medium infiltration and erosion were obtained with NaCMC tablets. The data of the release rate studied were subjected to kinetic treatment in an attempt to obtain linear correlations