Heterocyclic synthesis with biologically active S-[6-aryl pyridazin 3-yl] thioglycollic acid hydrazides

A number of S-[6-ary1pyridazin-3-yl] thioglycollic acid hydrazides [Ia-c] and thiosemicarbazide derivatives IIa-c have been prepared. 6-Arylpyridazin-3-mercaptomethenyl[4-phenyl--l,2,4-triazolo-5-thiones] [IIIa-c]; 6-arylpyridazin-3-mercaptometheny]-[4-phenyl-l,2,4-triazolo-5-mercaptomethyl ether [IVa]; 6-aryl pyridazin-3-mercaptomethyl-[4-phenyl-I,2,4-triazolo-5-mercaptocyanoethyl] [IVb] and the Mannich bases Va-c have been synthesized from III. The 6-arylpyridazin-3-mercaptomethenyl [5-aminophenyl-l,3-4-thiadiazolines] [VIa-c] and the corresponding 1,3-4-oxadiazoline derivative VII have been synthesized from the phenyl-thiosemicarbazide derivatives IIa-c. The antibacterial activity of the prepared compounds has been screened

Synthesis and antimicrobial activity of some nitrogen heterocycles incorporation into coumarin

Substituted 3-carbethoxycoumarin [Ia] was reacted with aromatic primary amines e.g. aniline and o-toludine to give N-substitntcd carbox amides [IIa.b][12], respectively. Also, when 3-carbethoxycoumarin derivatives [Ia-c] were reacted with aromatic hetercyclic amines such as 2-aminopyridine, 2-amino-thiazole, 2-aminobenzothiazole and 3-methyl-5-ethoxypyroyle the products are N-substituted carboxamidocoumarins, [IIIa-e] and [IV], respectively. Mass spectrum for the compound [IIId] shows ion peaks fragmentation at m/z 400/402 and other peaks at m/z 251/252 m/z 172 m/z 74. Alcoholic ferric chloride test doesn't give any definite colour of phenol[3], i.e. the alpha-pyrone ring is not cleavage