RESUMO
Vitamin E administration prevented DEHP induced deleterious effects like (i) degenerative changes in the brain and thyroid, (ii) decrease in the activity of neuronal membrane Na+ - K+ ATPase, (iii) decrease in the concentration of insulin, cortisol and TSH, and (iv) the increase in T3 and T4 in female Albino rats. The results suggest use of vitamin E to prevent harmful effects of repeated transfusion of DEHP containing blood as in thalassemia patient. The possibility of using vitamin E to prevent the harmful effects of repeated transfusion of DEHP containing blood, as in thalassemia patients, is discussed.
Assuntos
Animais , Glicemia/metabolismo , Preservação de Sangue/métodos , Transfusão de Sangue/métodos , Dietilexilftalato/farmacologia , Feminino , Hidrocortisona/metabolismo , Insulina/metabolismo , Plastificantes/química , Cloreto de Polivinila/química , Ratos , Ratos Wistar , ATPase Trocadora de Sódio-Potássio/metabolismo , Tireotropina/metabolismo , Vitamina E/uso terapêuticoAssuntos
Adulto , Biópsia/instrumentação , Duodenoscópios , Duodeno , Feminino , Corpos Estranhos/terapia , Humanos , Agulhas , Antro Pilórico , Instrumentos CirúrgicosRESUMO
A double blind, randomised, placebo controlled clinical trial was carried out in endoscopically proved chronic duodenal ulcer patients to compare the efficacy of sucralfate and ranitidine. Sucralfate 1 g four times daily and ranitidine 150 mg twice daily were found to be equally effective in inducing ulcer healing (73.1% and 82.1% respectively) during the 6-week treatment period. The rate of recurrence of the ulcer within six months after the initial treatment (84.2% and 82.6%) was also comparable in the sucralfate and ranitidine groups. Sucralfate and ranitidine are equally effective in ulcer healing and prevention of ulcer relapse.