Effect of aspirin on the immune response in rabbits

Twenty adult New Zealand white rabbits were divided into four equal groups. The first three groups were orally administered with 100, 200 and 400 mg/kg B.W./day of aspirin respectively for 14 days to study the effect of aspirin on the immune reponse in the rabbits. The results showed that the aspirin induced a significant increase of the WBCs in a the dose 100 and 200 mg/kg B.W. and this effect was pronounced in group which received 400 mg/kg B.W. However, the percentage of lymphocytes was also significantly elevated while the monocytes and basophils showed decline

Induction of immune complex glomerulonephropathy in rabbits exposed to formalin vapour: a condition resembling human goodpastures syndrome

Forty two rabbits were used to induce glomerulonephropathy by exposure to 10% formalin vapour. Seven groups of rabbits were exposed to formalin vapour at a rate of twenty three hours per day and one hour ventilation for eight successive months. The results showed that IgG was deposited in 50% of the glomeruli accompanied by histological changes occurred in most of the glomerular tufts. The lesions all together resembeled Goodpastures syndrome of man