Serum lipid alterations in retinopathy of type I [insulin-dependent] diabetes mellitus

Serum lipoproteins were measured in 36 type I [insuth dependent] diabetics with stages of retionpathy. Eleven patients of the 36 were without retinopathy 10 having exudative retinopathy [ER] and 15 with proliferative type [PR], along with 20 healthy volunteers. Serum triglyceride [TG] concentration and the ratio of high density lipoprotein cholesterol [HDL-CH]/low density lipoprotein lesterol [LDL.CH] were significantly increased in patients with PR and ER Moreover, diabetic retinopazhs had showed a significant correlation of serum TG with HDL-CH/T-CH ratio. Serum total cholesterol [CT-CR] and LDL-CH valuse were significantly increased in diabetics with PR and NR only. Serum HDL-CR values were similar in all groups. Lipid alterations were increased with the severity of retinopathy. Diabetic retinopathies had exhibited no significant correlation of serum Fructosamine with fasting serum glucose or any lipid fractions. The mean age and duration of diabetes were low in patients with PR and ER with a good correlation of T-CH with mean diastolic blood pressure in these patients. The study confirms that development and progression of retinopathy were the resultant of both prolonged hyperglycemia [with intermittent fluctuations of the blood glucose] and disordered lipid metabolism

Serum lipid alterations in retinopathy of type II [non-insulin dependent] diabetes mellitus

Fasting serum glucose, fructosamine, lipids, and lipoproteins were measured in 49 non-insulin dependent diabetics. Of these, 15 were without retinopathy, 12 with exudative type, and 22 with proliferative retinopathy. The groups were closely matched for age, sex, and duration of diabetes. The increased serum fructosamin values were significant correlated with high serum glucose in diabetic retinopathy [P< 0.001] and non-retinopaths [P< 0.01]. Nevertheless, all diabetic groups had exhibited no s relationship of serum fructosamine and main lipids or lipoprotien fractions. The means of serum triglyceride [TG], total cholesterol [TCH], very low density lipoprotein cholesterol [VLDL-CH], and low density lipoprotein cholesterol [LDL-CH] were significantly increased with the severity of retinopathy. High density lipoprotein cholesterol [HDL-CH] concentrations in all diabetic groups were comparable to their corresponders of 22 healthy controls. A high ratio of LDL-CH/HDL-CH was observed only in proliferative type [P< 0.05]. Adjustment for different treatment modalities had revealed alteration in serum lipid fractions among other groups