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1.
Artigo em Inglês | IMSEAR | ID: sea-95011

RESUMO

OBJECTIVE: The aim of this study was to determine the safety and efficacy of adenosine Tc99m sestamibi myocardial perfusion study under controlled conditions and to correlate the adenosine Tc99m sestamibi perfusion defects and the coronary angiography in patients investigated for coronary artery disease. METHODS: This prospective study included 122 consecutive patients who underwent adenosine Tc99m sestamibi single photon emission computed tomography (SPECT) myocardial perfusion study. Seventy two patients had coronary angiographic correlation. All the patients who were referred by the cardiologists for stress myocardial perfusion scan who could not be stressed physiologically for one reason or the other were included in the study. RESULTS: Among the coronary angiography group the overall sensitivity, specificity, positive predictive value and negative predictive value of adenosine Tc99m sestamibi single photon emission computed tomography myocardial perfusion study for detecting significant coronary obstruction (diameter > or = 50%) were 94.4%, 79%, 85% and 92% respectively. The side effects were transient and required no treatment. CONCLUSION: We conclude adenosine Tc99m sestamibi single photon emission computed tomogram myocardial perfusion study is a reliable test with high sensitivity and specificity for the detection of coronary artery disease.


Assuntos
Adenosina/diagnóstico , Adulto , Idoso , Angiografia Coronária , Circulação Coronária/efeitos dos fármacos , Doença das Coronárias/diagnóstico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Compostos Radiofarmacêuticos/diagnóstico , Sensibilidade e Especificidade , Tecnécio Tc 99m Sestamibi/diagnóstico , Tomografia Computadorizada de Emissão de Fóton Único , Vasodilatadores/diagnóstico
2.
Artigo em Inglês | IMSEAR | ID: sea-88628

RESUMO

A young female presented with haemolytic anaemia due to dapsone overdosage. She developed peripheral neuropathy and marked visual impairment with a cherry red spot on the macula, possibly due to toxic retinal vascular damage; both these resolved in due course. Cherry red spot due to dapsone poisoning has not been reported previously.


Assuntos
Adolescente , Anemia Hemolítica/induzido quimicamente , Dapsona/intoxicação , Feminino , Humanos , Hanseníase Tuberculoide/tratamento farmacológico , Macula Lutea/patologia , Doenças do Sistema Nervoso Periférico/induzido quimicamente
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