RESUMO
A young girl presented to us with recurrent diarrhea along with a history of 5 kg weight loss in one year. On examination, she appeared pale, while her laboratory reports showed a low hemoglobin, mean corpuscular volume [MCV] and serum albumin. Her erythrocyte sedimentation rate [ESR] was slightly raised with her iron profile suggestive of iron deficiency anemia. Viral markers, human immunodeficiency virus [HIV] serology along with thyroid profile were all unremarkable. There was no history of tuberculosis, and purified protein derivative [PPD] skin test was also negative. Computed tomography [CT] abdomen showed thickening of the terminal ileum with multiple enlarged lymph nodes. An esophagogastroduodenoscopy [EGD] along with colonoscopy was done. Multiple biopsies were taken, which were suggestive of sprue along with intestinal spirochetosis. Her tissue transglutaminase [TTG] was negative while deamidated gliadin peptide [DGP] was positive. She was kept on gluten-free diet and started on tablet metronidazole. This case shows that intestinal spirochetosis should be kept in mind in patients belonging to lower socio-economic status, who present with chronic diarrhea symptoms
RESUMO
A 13-year-old boy, known case renal stone disease came with the complaints of abdominal pain along with low grade fever. On examination, hepatosplenomegaly was noted while his lab reports showed a low hemoglobulin with a raised ESR. His blood and urine cultures showed no growth. Viral markers, autoimmune profile, C and p ANCA were all negative apart from a raised serum IgG level. Ultrasound abdomen showed a hyperechoic liver with an enlarged spleen along with splenic varices and minimum ascites. Ultrasound hepatic doppler was normal. Serum AFP levels were normal while workup for Wilson's disease was negative. Fibroscan showed F4 fibosis. CT scan abdomen showed an enlarged left lobe of the liver along with an enlarged spleen. His EGD revealed varices. So liver biopsy was done that was suggestive of chronic granulomatous disease with ZN stain testing negative for TB.PPD, urine for AFB were both negative. Serum ACE levels were raised. He started ATT therapy but his condition did not improve. So, on the suspicion of hepatic sarcoidosis, he started on steroids and had a drastic improvement in his condition
RESUMO
Aim: Is Karnofsky Performance Status [KPS] a predictor of 3 month post discharge mortality in cirrhotic patients?
Background: Cirrhotic patients often experience an abrupt decline in their health, which often leads to frequent hospitalization and can cause morbidity and mortality. Various models are currently used to predict mortality in cirrhotics however these have their limitations. The Karnofsky Performance Status [KPS] being one of the oldest performance status scales, is a health care provider - administered assessment that has been validated to predict mortality across the elderly and in the chronic disease populations
Methods: We used the KPS performance status scale to envisage short-term mortality in cirrhotic and HCC patients who survive to be discharged from hospital
Results: Our study showed that KPS one week post-discharge, child pugh score, hospital stay, international normalized ratio, serum albumin, total bilirubin and serum creatinine showed statistical significance on univariate analysis. On multivariate analysis, KPS was found to be statistical significant predictor of 3-month mortality
Conclusion: Hence KPS can be utilized to identify cirrhotic patients at risk of 3-month post discharge mortality
RESUMO
Acute liver failure [ALF] is an acute medical emergency which carries high mortality without liver transplantation. Various hepatotropic viruses, drug induced liver injury, auto immune hepatitis, and metabolic liver diseases are the commonly implicated etiologic agents. Liver involvement in dengue hemorrhagic fever [DHF] is quite common, but acute liver failure is its rare complication. Neurological complications are also commonly seen in DHF. A teenage girl presented with high grade fever and subconjunctival hemorrhage, and later developed jaundice due to acute liver failure. Liver transplantation could not be offered due to fungemia. During hospital stay, she had seizures and intracranial hemorrhage culminating in brain death. ALF with neurological involvement is a rare but very important and fatal complication of DHF; and it should be considered as a cause of acute liver failure, especially in endemic areas
RESUMO
Objective: To determine the causes, characteristics and predictors of mortality in patients with acute-on-chronic liver failure [ACLF]
Study Design: Cross-sectional study
Place and Duration of Study: Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi, from July 2014 to June 2016
Methodology: All patients with acute-on-chronic liver disease [ACLD] with ages > 12 were included. Patients with ACLF, as defined by the Asian Pacific Association for the Study of Liver [APASL, 2014] were identified. Predictors of mortality were identified using chi-square or Fisher's exact test
Results: Included in the study were 72 patients with mean age of 36.71 years, 46 [63.9%] being males. Among them, 61 developed ACLF. Commonest causes of chronic liver disease [CLD] were chronic viral hepatitis [37, 51.4%] and autoimmune hepatitis [14, 19.4%]. Commonest causes of acute liver injury [ALI] were acute viral hepatitis [24, 33.3%] and drug induced liver injury [DILI] [17, 23.6%]. Among those with ACLF, 24 [39.3%] patients died with median survival of 17.1 +/- 13.5 days. Mortality was significantly associated with Child Turcotte Pugh [CTP] score >/=13 [p=0.010], model for end-stage liver disease [MELD] score >/=30 [p=0.001], age >40 years [p=0.036], organ failures [OF] >/=3 [p <0.0001], portosystemic encephalopathy [PSE] [p <0.0001], renal failure [p <0.0001] and urosepsis [p <0.0001]
Conclusion: Acute viral hepatitis and DILI are commonest causes of ACLF. Mortality is high in ACLF patients having OF >/=3, CTP >/=13, MELD >/=30, age >40 years, PSE, renal failure and urosepsis