Congenital adrenal hypoplasia: a disorder frequently missed

Congenital adrenal hypoplasia is a rare disease which is known to cause severe salt wasting in the neonatal period. In this report, we describe three patients from two different families who were seen at King Khalid University Hospital, Riyadh, Saudi Arabia. All patients presented with classical clinical, biochemical, hormonal and radiological findings of congenital adrenal hypoplasia. To the best of our knowledge, no similar cases were reported from this part of the world

Oestrogen-secreting adrenocortical adenoma causing gynecomastia in a prepubertal boy

An 8-year-old boy with isolated gynaecomastia is described. In addition to elevated serum oestradiol, levels of dehydroepiandrosterone sulphate, androstenedione and testosterone were low with normal cortisol, suggesting pure-oestrogen secreting tumour. An adrenocortical adenoma was surgically removed. The oestradiol level returned to normal with gradual regression of the breast size and normal growth velocity. A brief review of the literature on feminizing adrenocortical tumours in boys is presented