RESUMO
To evaluate the effect of high dose thiamine on postprandial blood glucose [PPBG] and hemoglobin A 1C levels in induced diabetic albino rat model. Experimental/Analytical study. Animal House, Isra University Hyderabad from March to October 2013. Forty adult albino rats were divided into four groups; Group I. Controls receiving normal diet, Group II. Controls receiving thiamine fortified diet, Group III. Diabetics receiving normal diet and Group IV. Diabetics receiving thiamine fortified diet. Diabetes mellitus was induced using Streptozocin. Thiamine was given at a dose of 1.6 g/kg body weight. Venous blood samples were drawn from animal's tail with a small bore cannula before and after 12 weeks of experimentation. The PPBG levels and Glycosylated HbA [HbA1c] were measured. The data was converted into database and analyzed on SPSS version 21.0 by ANOVA and Tukey-Kramer's test. A p-value of