Synergistic potential of Zingiber officinale and Curcuma longa to ameliorate diabetic-dyslipidemia

To find the cure of world's one of the leading morbid and mortal disorders; diabetes mellitus and its most prevalent complication, 'diabetic-dyslipidemia', is one of the leading health challenges of 21st century. The use of phytomedicine is a glimmer of hope in this scenario. Studies of current decade have shown that methanolic extracts of Zingiber officinale and Curcuma longa have highly effective therapeutic potentials against the aforesaid disorders, however, which of the extracts has more potential is still unclear. Furthermore, synergistic effect of the extracts has never been studied. Forty-eight Albino adult rats of either sex were randomly divided into eight groups. A-D groups were containing healthy rats while E-H groups were of induced diabetic-dyslipidemic rats. For forty-two days, rats of each group were given either distilled water or Zingiber officinale methanolic extract [ZOME] or Curcuma longa methanolic extract [CLME] or ZOME+CLME therapies at dose rate of 300mg/100 mL dist. H2O/kg body wt/day. FPG and lipid profiles were estimated before and after the trial, and were statistically analyzed by one-way ANOVA along with Posthoc Tukey's multiple comparison tests. Although, ZOME and CLME significantly [P<0.05] lowered fasting plasma glucose [FPG] levels and controlled lipid profiles in diabetic-dyslipidemic rats; yet, synergistic therapy of both extracts [ZOME+CLME] most significantly [P<0.05] controlled all parameters of diabetic-dyslipidemia [78.00 +/- 1.06mg/dL FPG, 62.00 +/- 0.58mg/dL TG, 66.50 +/- 0.76mg/dL cholesterol, 32.00 +/- 0.36mg/dL HDL, 22.43 +/- 0.64 mg/dL LDL, and 12.40 +/- 0.12mg/dL VLDL]. Our findings may be useful to formulate new medicines having multiple potentials to control diabetes mellitus, dyslipidemia, and diabetic-dyslipidemia

Renal transplant recipients; pattern of lipid abnormalities and their relationship to HBA1C

Good glycemic control and lipid modification are potentially important intervention for improving outcome after kidney transplantation. To determine the frequency of dyslipidemia and its types in renal transplant recipients [RTRs], and to observe impact of hyperglycemia on their lipid profile. Case control study. June 2011 to May 2012. Kidney Dialysis Department of Jinnah Hospital Lahore, Urology Department of Mayo Hospital Lahore and Pathology Department Allama Iqbal Medical College Lahore. A total of 40 RTR were included in the study. An equal number of sex and age matched healthy subjects were considered as control group. The patients were on regular post transplant follow up in Kidney Dialysis Department of Jinnah Hospital Lahore and Urology Department of Mayo Hospital Lahore and had no clinical or laboratory evidence of graft rejection, post-transplant diabetes mellitus, hypertension or inter current infection. Total cholesterol [TC], triglyceride [TG], High density Lipoprotein-Cholesterol [HDL-C], and Glycohemoglobin A1c [HbA1c] were estimated in all subjects. These subjects were divided into Diabetic and non-diabetic groups, according to level of HbA1c. The mean age of the RTR was 34.5 +/- 9.02 years and the mean duration of transplant was 36.70 +/- 38.07 months. RTRs showed significantly high mean levels of TG [p< 0.002], TC [p< 0.00], LDL-C [p< 0.01], and HDL-C [p< 0.05] as compared to the control subjects. Elevated TC, TG, LDL-C and low HDL was observed in 32.5%, 72.5%, 52.5%, and 60% of total RTR, respectively. The mean levels of TC, TG and HDL-C were increased in Diabetic transplant group as compared to non-diabetic RTR. Percentage of elevated TC, TG, LDL-C and decreased HDL in diabetic group of RTR versus non diabetic RTR was 43.7% Vs 25%, 81.2% Vs 66.6%,, 62.5% Vs 44.4%, and 50% Vs 66.6% respectively. There was a positive relationship between HbA1c and lipid profile [TC, TG, and LDL - C] in both Diabetic and Non Diabetic Group. A statistically significant correlation of the mean HbA1c levels with TG level was observed in Diabetic RTR. Dyslipidemia in our RTRs was observed as elevated levels of TC, TG and LDL-C. In diabetic RTR, a statistically significant positive correlation of the HbA1c levels with TG level was observed. More rigorous glycemic control and lipid modification will reduce the development of microvascular complications

Role of external fixator in the management of trochanteric fractures of the femur - damage control orthopaedics

To compare the Modified AO fixator [MAO] with sliding hip screw [SHS] in the treatment of trochanteric fractures. 68 patients of both genders presenting with trochanteric fractures at Combined Military Hospital Lahore. This was a Prospective, Randomized Study. This study was conducted at the in patient surgical Unit at Combined Military Hospital Lahore from 1st June 2006 till 30 November 2007. 68 high risk patients of ASA-IVa-c with a trochanteric fracture were selected. The mean age was 73 yrs +/- . There were 17[28%] males and 45 [72%] females. There was no delay between injury and operation when treated by external fixation [mean 3.13 days, 1 to 7]. All fractures in group I united clinically and radiologically at 24 weeks. The surgery required lesser time [mean 29.35 minutes, 20 to 45], the blood loss was minimal [mean= 33.33 ml] and required a short hospital stay [mean of 3.96 days, range 2 to 7 days] as compared to the group II. At the final follow-up, 03 [8%] patients had shortening or malrotation, 02[03%] patients had varus angulation, implant failure [pin breakage] in one patient [1.4%] and pin cut out was observed in one [1.4%]. Our results confirm that the Modified AO fixator is an effective device for treating pertrochanteric fractures and is a useful alternative to conventional fixation with the sliding hip screw