GATA Binding Protein 3 (GATA-3) expression evaluation as prognostic factor in breast cancer and its relationship with other immunemarkers

Introduction: Breast cancer is the most frequent cancer in which the mortality rate could be decreased by proper management. The GATA3 transcription factor is one of the most frequently mutated genes in breast cancer. Materials and Methods: We studied the immunohistochemical (IHC) expression of estrogen and progesterone receptor, human epidermal growth factor receptor 2, and GATA-3 in 166 radical/partial mastectomy specimens having different histologic grades and stages of breast carcinoma. All samples were obtained from the pathology department of Sina hospital in Tehran-Iran from 2010 to 2016. Results: There was a direct relationship between the luminal subtype carcinoma and higher GATA-3 expression (P-value: 0.001) and between triple-negative carcinoma and lower GATA-3 expression (P-value: 0.001). Moreover, there was a direct relationship between the metastasis rate and the tumor's grade with GATA-3 staining (P-value: 0.000 and 0.001, respectively). Conclusion: GATA-3 expression is related to the histopathologic and prognostic factors. GATA3 can be introduced as an important predictor in breast cancer patients.

Evaluation of the histopathologic status of rectal adenocarcinoma and its regional lymph nodes after neoadjuvant therapy, and its relation to the duration of disease-free survival

Introduction: Colorectal cancer is one of the most common malignant tumors and has a relatively poor prognosis. Lymph node involvement is considered the most important prognostic factor. Materials and Methods: During a retrospective cohort study, 132 patients with locally advanced rectal cancer who underwent neoadjuvant chemoradiotherapy followed by surgery for resectable rectal cancer from 2010 to 2015 in Sina hospital were reviewed. Results: Multivariable analysis was performed and shown the clinical stage was not a representative factor for disease-free survival (P = 0.187), but Dworak Tumor Regression Grading were significantly associated with higher disease-free survival (P = 0.000) in stage II and stage III. The total number of retrieved lymph nodes and involved lymph nodes in the same clinical stage were statistically associated with higher mean disease-free survival in patients (P = 0.000 in both conditions). Conclusion: In the same clinical stage, increasing the Dworak Tumor Regression Grading reduced the risk of rectal cancer recurrence. Increasing total number of retrieved lymph nodes and involved lymph nodes, 2.14 times and 3.87 times increased the risk of recurrence, respectively.

Seroprevalence of hepatitis B and C viruses among tuberculosis patients

Tuberculosis is a common health problem in the world. Sudan is among the countries with the highest prevalence for tuberculosis and HBV, HCV infections. Co-infection with viral hepatitis [HBV, HCV] among tuberculosis patients increases the risk of hepatotoxicity occurring during tuberculosis treatment, so it is important to know the seroprevalence of hepatitis B and C viruses among tuberculosis patients. To investigate seroprevalence of HBV and HCV among adult tuberculosis patients in tuberculosis center at Tropical Diseases Teaching Hospital [TDH]. This is a prospective cross sectional study, conducted in the period from December 2010 to October 2011 in tuberculosis center in TDH- Sudan. 200 adult tuberculosis patients [age 19years and above] were enrolled in this study, data were collected by using questionnaire. All patients' blood samples were tested for HBsAg and hepatitis C virus antibodies. Results were analyzed by using SPSS16 [Statistical package for social science16]. A total number of 200 confirmed tuberculosis patients were studied. 127 patients [63.5%] were males. The seroprevalence of HBV and HCV in this study were9.5% and 3.5% respectively.Two patients [1%] were infected with both infections. The HBV vaccination among the study group was 6%.The HBV and HCV infections are common among tuberculosis patients with seroprevalence of 9.5%and 3.5% for HBV and HCV respectively. Our study also showed that there are multiple risk factors for contracting HBV and HCV infections in our patients, so screening for these viruses should be included in the national TB control program.

Infiltración leucemica de la próstata: presentación de un caso / Laukemic infiltration of the prostate

La infiltración leucémica de la próstata no es un hallazgo clínico habitual. La mayoría de los casos se deben a la leucemia linfocítica crónica. Estaría indicada la realización de una biopsis prostática en todod paciente leucémico con síntomas obstructivos del tracto urinario inferior

Fluoride absorption among workers of lamps factors

41 workers exposed to fluoride. and 28 non-exposed workers were studied. No significant difference in mean urinary fluoride level [MUFL] was observed between male and female workers, and between Iraqi and Chinese workers. There was significance difference between the pro and post-shift MUFL. A strong correlation was observed between MUFL and duration of exposure, and also between MUFL. and air fluoride level. It is suggested that MUFL might be considered as a good index of fluoride absorption