RESUMO
The present study was designed to investigate gallic acid-4-O-β-glucopyranoside (GAGP) in normal and alloxaninduced diabetic rats by a single dose administration of alloxan (150 mg/kg, i.p.). Blood glucose levels measured weresignificantly (p < 0.05) increasing in all diabetic rats as compared with normal control rats. Three different dosagesof GAGP (100, 200, and 400 mg/kg, body weight) showed significantly decreasing (p < 0.05) blood glucose levelsof the diabetic rats (<3%) as compared with untreated diabetic group (>66%). All the hyperglycemic groups whichwere treated with various dosages of GAGP recorded lower biochemical parameters of blood serum as compared withuntreated diabetic group. A significant reduction in catalase activity (<40%–60%) of the diabetic groups was observedas compared with control group, while the diabetic groups showed elevation as compared with untreated diabeticgroup and catalase activity was quite near to normal rats. Glutathione levels of the diabetic groups were reduced(<2%–3%) but diabetic treated groups with different dosage showed improvement near to normal rats. In diabeticrat tissue, significant elevation (>45%) in lipid peroxidation was observed as compared with normal rats. In contrast,treatment with GAGP restores back near towards normal level (>5%–15%).