Advanced maternal grandmother age and maternal age as risk factors for down syndrome in a group of Jordanian families

To study whether advanced maternal age and maternal grandmother age are associated with increased risk of Down syndrome siblings in a group of Jordanian families. This study was conducted on 127 confirmed Down syndrome cases with the age range of 18 weeks gestation to 15 years old, which were referred between the period of 2005-2008 for cytogenetic analysis at the Cytogentics section, Princess Iman Research and Laboratory Sciences Center/King Hussein Medical Center. Maternal and grandmaternal mother ages were obtained directly from the study group when the samples were collected from siblings. The maternal age ranged between 19-45 years while the maternal grandmother's age ranged between 15-49 years. One hundred healthy families were randomly recruited from the hospital staff as a control group. Logistic regression was used for statistical analysis. One hundred seventeen down syndrome cases had free trisomy 21,7 with translocation, 2 mosaic and one with double aneuploidy [47,XXY, +21]. Fifteen cases were diagnosed prenatally while 112 were diagnosed postnatally. The effect of maternal age and maternal grandmother age were found to be significant using logistic regression statistics [P = 0.001; OR= 2.816; 95% CI, 1.48-5.33] for the mother's age and [P = 0.001; OR= 2.902; 95%CI, 1.521-5.53] for the grandmother's age. Advanced maternal and maternal grandmother ages are risk factors for Down syndrome. More studies and investigations are needed for better understanding of the biological factors responsible for the proper meiotic segregation of germ cells during the fetal development of the embryo in advanced maternal and grandmother's age

CD30+ anaplastic large cell lymphoma in leukemic phase: a case report

Patients with Ki [CD3O] positive anaplastic large cell lymphoma occasionally have rare circulating lymphoma cells. This report describes a case of anaplastic large cell lymphoma with prominent leukemic phase. A 61 years old man presented with widespread anaplastic large cell lymphoma involving lymph nodes, skin, peripheral blood, and bone marrow. His white blood count was 241.500/mm with 82% lymphoma cells. The circulating neoplastic cells were large and had irregular nuclei, multiple small nucleoli, and multiple clear cytoplasmic vacuoles. This case illustrates that anaplastic large cell lymphoma may have a marked leukemic phase of large anaplastic cells